Relation Results

Summary

Name PCGF2
Full Name Polycomb group RING finger protein 2
Synonyms DNA-binding protein Mel-18, RING finger protein 110, Zinc finger protein 144 | MEL18, RNF110, ZNF144
Primary ID P35227
Links - -
Type protein
Relations 4
Function Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell p ...
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Type: Score: Layout: SPV 
0.20.5930.7690.33Ub:E2PCGF2UBE2IPolycomb repressive complex 1HSF2

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Relations
Regulator
Mechanism
target
score ℹ
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination PCGF2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271089 Homo sapiens
pmid sentence
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t
Publications: 1 Organism: Homo Sapiens
+ PCGF2down-regulates activity img/direct_inhibition.png binding UBE2I 0.593
Identifier Residue Sequence Organism Cell Line
SIGNOR-226248 Homo sapiens HEK-293 Cell
pmid sentence
Based on this finding of interaction between MEL-18 and UBC9, we envisioned a mechanism in which MEL-18 bound to HSF2 inhibits its sumoylation by binding to and inhibiting the activity of UBC9 enzymes that approach HSF2.
Publications: 1 Organism: Homo Sapiens
+ PCGF2form complex img/form-complex.png binding Polycomb repressive complex 1 0.769
Identifier Residue Sequence Organism Cell Line
SIGNOR-266813 Homo sapiens
pmid sentence
PRC1 has been categorised into canonical and noncanonical/variant PRC1; canonical PRC1 (Morey, Aloia, Cozzuto, Benitah, & Di Croce, 2013) includes chromobox (Cbx) proteins, Ring1, human polyhomeotic homologue protein (Hph) and polycomb ring finger (Pcgf) (Pcgf2/Mel18 and Pcgf4/Bmi1) proteins whereas noncanonical/variant PRC1 involves RING1 and YY1 binding protein (Rybp), Ring1 and Pcgf (Pcgf 1–6) proteins (Wu, Johansen, & Helin, 2013). Figure 3 illustrates the various proteins that form the canonical and noncanonical PRC1. The Ring1 along with Pcgf2/4 forms a core heterodimer which interacts with other accessory components of PRC1 complex through C‐terminal ring finger and WD40 ubiquitin‐like (RAWUL) domains see Figure 4b
Publications: 1 Organism: Homo Sapiens
+ PCGF2down-regulates activity img/direct_inhibition.png sumoylation HSF2 0.33
Identifier Residue Sequence Organism Cell Line
SIGNOR-226245 Homo sapiens HEK-293 Cell
pmid sentence
MEL-18, in contrast to the polycomb protein PC2/CBX4, in which SUMO E3 activity stimulates sumoylation of certain proteins, actually functions like an anti-SUMO E3 protein, interacting with both HSF2 and the SUMO E2 UBC9 but acting to inhibit UBC9 activity and thereby decreasing sumoylation of a target protein, in this case that of HSF2. sumoylation of HSF2 is up-regulated during mitosis and is important for the interaction of this factor with a subunit of the condensin complex during the bookmarking process
Publications: 1 Organism: Homo Sapiens
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