Relation Results

Name	TRIM23
Full Name	E3 ubiquitin-protein ligase TRIM23
Synonyms	ADP-ribosylation factor domain-containing protein 1, GTP-binding protein ARD-1, RING finger protein 46, RING-type E3 ubiquitin transferase TRIM23, Tripartite motif-containing protein 23 \| ARD1, ARFD1, RNF46
Primary ID	P36406
Links	- -
Type	protein
Relations	3
Function	Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes (PubMed:28871090).