Summary

Name PPARG
Full Name Peroxisome proliferator-activated receptor gamma
Synonyms PPAR-gamma, Nuclear receptor subfamily 1 group C member 3 | NR1C3
Primary ID P37231
Links - -
Type protein
Relations 90
Pathways Macrophage differentiation, Adipogenesis, MTOR Signaling, Thyroid cancer, FAP: IL4, FAP: insulin-mediated adipogenesis
Function Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation PPARG 0.10
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage differentiation
+ down-regulates activity img/direct_inhibition.png phosphorylation PPARG
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Thyroid cancer
+ down-regulates activity img/direct_inhibition.png phosphorylation PPARG
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation, relocalization PPARG 0.08
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation, relocalization PPARG
Publications: 7 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PPARG
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, MTOR Signaling, Thyroid cancer
+ down-regulates img/indirect_inhibition.png unknown PPARG 0.02
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown PPARG 0.04
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png unknown JUN 0.13
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PPARG 0.04
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CTNNB1 0.15
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid cancer
+ down-regulates img/indirect_inhibition.png unknown PPARG 0.03
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png transcriptional regulation PPARG 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png unknown PPARG 0.03
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation PPARG
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown PPARG
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ down-regulates img/direct_inhibition.png relocalization HDAC1
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown PPARG
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation PPARG 0.10
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
Pathways:Adipogenesis
+ up-regulates activity img/direct-activation.png binding PPARG
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG
Publications: 2 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates activity img/indirect-activation.png unknown PPARG
Publications: 1 Organism: Mus Musculus
Pathways:MTOR Signaling
+ up-regulates img/direct-activation.png binding PPARG
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation PPARG
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png unknown PTEN 0.16
Publications: 1 Organism: Homo Sapiens
Pathways:MTOR Signaling, Thyroid cancer
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PPARG 0.05
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PPARG
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PPARG
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG 0.31
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis, FAP: insulin-mediated adipogenesis, MTOR Signaling
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PPARG
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/indirect-activation.png unknown PPARG 0.03
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity img/indirect-activation.png transcriptional regulation PPARG
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ down-regulates activity img/direct_inhibition.png transcriptional regulation PPARG
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png unknown PPARG
Publications: 1
Pathways:Adipogenesis, FAP: insulin-mediated adipogenesis
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PPARG
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation Adipogenesis
Publications: 1 Organism: Mus Musculus
Tissue: Mammary Epithelial Cell
Pathways:Adipogenesis, FAP: insulin-mediated adipogenesis, MTOR Signaling
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation PPARG
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation PPARG
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Tissue: Liver
+ up-regulates activity img/direct-activation.png binding PPARG
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PPARG
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation PPARG
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CPT1B 0.10
Publications: 1 Organism: Mus Musculus
+ down-regulates img/indirect_inhibition.png unknown PPARG
Publications: 1 Organism: Homo Sapiens
Pathways:FAP: IL4, Macrophage differentiation
+ down-regulates activity img/direct_inhibition.png transcriptional regulation PPARG
Publications: 1
+ down-regulates activity img/direct_inhibition.png transcriptional regulation PPARG
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ABCG2 0.09
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png unknown PPARG
Publications: 1
+ down-regulates img/direct_inhibition.png binding PPARG 0.04
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding PPARG 0.03
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/direct-activation.png binding PPARG
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Thyroid cancer
+ up-regulates img/indirect-activation.png transcriptional regulation CEBPA 0.18
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FABP4 0.29
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG 0.05
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG 0.08
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates img/indirect-activation.png unknown M2 polarization
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage differentiation
+ up-regulates img/indirect-activation.png unknown PPARG
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png transcriptional regulation PPARG 0.04
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png transcriptional regulation PPARG 0.05
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG 0.04
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG 0.03
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG 0.06
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png phosphorylation PPARG
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis, MTOR Signaling, Thyroid cancer
+ up-regulates img/direct-activation.png binding PPARG 0.46
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPARG 0.07
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation FABP4
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png binding PPARG 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPARG 0.05
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png transcriptional regulation PPARG
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG
Publications: 1 Organism: Homo Sapiens
Pathways:FAP: IL4, Macrophage differentiation
+ down-regulates quantity by repression img/indirect_inhibition.png unknown NfKb-p65/p50
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage differentiation
+ down-regulates img/indirect_inhibition.png unknown STAT3 0.10
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage differentiation
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PPARG
Publications: 1 Organism: Rattus Norvegicus
Pathways:Adipogenesis, FAP: insulin-mediated adipogenesis
+ up-regulates img/indirect-activation.png unknown PPARG
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png unknown PPARG 0.15
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid cancer