Relation Results

Summary

Name NUDT1
Full Name Oxidized purine nucleoside triphosphate hydrolase
Synonyms EC 3.6.1.56, 2-hydroxy-dATP diphosphatase, 7,8-dihydro-8-oxoguanine triphosphatase, 8-oxo-dGTPase, Methylated purine nucleoside triphosphate hydrolase, EC 3.6.1.-, Nucleoside diphosphate-linked moiety X motif 1, Nudix motif 1 | MTH1
Primary ID P36639
Links - -
Type protein
Relations 2
Function Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool (PubMed:8226881, PubMed:7713500, PubM ...
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Type: Score: Layout: SPV 
0.20.254Cullin 1-RBX1-Skp1NUDT1SKP2

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Relations
Regulator
Mechanism
target
score ℹ
+ Cullin 1-RBX1-Skp1down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination NUDT1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-272791 Homo sapiens Mel-CV Cell
pmid sentence
Here, we report that MTH1 is regulated by polyubiquitination mediated by the E3 ligase Skp2. In melanoma cells, MTH1 was upregulated commonly mainly due to its improved stability caused by K63-linked polyubiquitination. Although Skp2 along with other components of the Skp1-Cullin-F-box (SCF) ubiquitin ligase complex was physically associated with MTH1, blocking the SCF function ablated MTH1 ubiquitination and expression. Conversely, overexpressing Skp2-elevated levels of MTH1 associated with an increase in its K63-linked ubiquitination. 
Publications: 1 Organism: Homo Sapiens
+ SKP2down-regulates quantity by destabilization img/direct_inhibition.png binding NUDT1 0.254
Identifier Residue Sequence Organism Cell Line
SIGNOR-272790 Homo sapiens Mel-CV Cell
pmid sentence
Here, we report that MTH1 is regulated by polyubiquitination mediated by the E3 ligase Skp2. In melanoma cells, MTH1 was upregulated commonly mainly due to its improved stability caused by K63-linked polyubiquitination. Although Skp2 along with other components of the Skp1-Cullin-F-box (SCF) ubiquitin ligase complex was physically associated with MTH1, blocking the SCF function ablated MTH1 ubiquitination and expression. Conversely, overexpressing Skp2-elevated levels of MTH1 associated with an increase in its K63-linked ubiquitination. 
Publications: 1 Organism: Homo Sapiens
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