Relation Results

Summary

Name	NUDT1
Full Name	Oxidized purine nucleoside triphosphate hydrolase
Synonyms	EC 3.6.1.56, 2-hydroxy-dATP diphosphatase, 7,8-dihydro-8-oxoguanine triphosphatase, 8-oxo-dGTPase, Methylated purine nucleoside triphosphate hydrolase, EC 3.6.1.-, Nucleoside diphosphate-linked moiety X motif 1, Nudix motif 1 \| MTH1
Primary ID	P36639
Links	- -
Type	protein
Relations	2
Function	Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool (PubMed:8226881, PubMed:7713500, PubMed:10608900, PubMed:12857738, PubMed:22556419, PubMed:26238318, PubMed:24695224, PubMed:24695225, PubMed:28679043). Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP (PubMed:10373420). Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP (PubMed:10373420, PubMed:11139615). Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A (PubMed:8226881, PubMed:10373420, PubMed:10608900, PubMed:11756418, PubMed:12857738, PubMed:16607562, PubMed:24695224, PubMed:24695225, PubMed:26999531, PubMed:28035004). Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA (PubMed:30304478, PubMed:32144205). Through this antimutagenic activity protects cells from oxidative stress (PubMed:8226881, PubMed:7713500, PubMed:10608900, PubMed:12857738, PubMed:24695224, PubMed:24695225, PubMed:30304478, PubMed:32144205). {ECO:0000269\|PubMed:10373420, ECO:0000269\|PubMed:10608900, ECO:0000269\|PubMed:11139615, ECO:0000269\|PubMed:11756418, ECO:0000269\|PubMed:12857738, ECO:0000269\|PubMed:16607562, ECO:0000269\|PubMed:22556419, ECO:0000269\|PubMed:24695224, ECO:0000269\|PubMed:24695225, ECO:0000269\|PubMed:26238318, ECO:0000269\|PubMed:26999531, ECO:0000269\|PubMed:28035004, ECO:0000269\|PubMed:28679043, ECO:0000269\|PubMed:30304478, ECO:0000269\|PubMed:32144205, ECO:0000269\|PubMed:7713500, ECO:0000269\|PubMed:8226881}.