| + |
GMPR | up-regulates quantity 
chemical modification
|
NADP(3-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280514 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33369428 |
The human GMPR enzyme maintains the intracellular balance between the adenine and guanine nucleotide pools. The chemical reaction of this enzyme proceeds by deamination and hydride transfer steps. In deamination, the thiol group of Cys186 reacts on C2 of 5GP to form an intermediate E-XMP. In the second step, nicotinamide moves adjacent to C2 of E-XMP to allow hydride ion transfer, resulting in the production of inosine-5′-monophosphate (IMP) (Figure S4). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GMPR | down-regulates quantity 
chemical modification
|
guanosine 5'-monophosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280509 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33369428 |
The human GMPR enzyme maintains the intracellular balance between the adenine and guanine nucleotide pools. The chemical reaction of this enzyme proceeds by deamination and hydride transfer steps. In deamination, the thiol group of Cys186 reacts on C2 of 5GP to form an intermediate E-XMP. In the second step, nicotinamide moves adjacent to C2 of E-XMP to allow hydride ion transfer, resulting in the production of inosine-5′-monophosphate (IMP) (Figure S4). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GMPR | down-regulates quantity
chemical modification
|
NADPH(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280510 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33369428 |
The human GMPR enzyme maintains the intracellular balance between the adenine and guanine nucleotide pools. The chemical reaction of this enzyme proceeds by deamination and hydride transfer steps. In deamination, the thiol group of Cys186 reacts on C2 of 5GP to form an intermediate E-XMP. In the second step, nicotinamide moves adjacent to C2 of E-XMP to allow hydride ion transfer, resulting in the production of inosine-5′-monophosphate (IMP) (Figure S4). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GMPR | down-regulates quantity
chemical modification
|
hydron |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280511 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33369428 |
The human GMPR enzyme maintains the intracellular balance between the adenine and guanine nucleotide pools. The chemical reaction of this enzyme proceeds by deamination and hydride transfer steps. In deamination, the thiol group of Cys186 reacts on C2 of 5GP to form an intermediate E-XMP. In the second step, nicotinamide moves adjacent to C2 of E-XMP to allow hydride ion transfer, resulting in the production of inosine-5′-monophosphate (IMP) (Figure S4). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GMPR | up-regulates quantity
chemical modification
|
IMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280512 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33369428 |
The human GMPR enzyme maintains the intracellular balance between the adenine and guanine nucleotide pools. The chemical reaction of this enzyme proceeds by deamination and hydride transfer steps. In deamination, the thiol group of Cys186 reacts on C2 of 5GP to form an intermediate E-XMP. In the second step, nicotinamide moves adjacent to C2 of E-XMP to allow hydride ion transfer, resulting in the production of inosine-5′-monophosphate (IMP) (Figure S4). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GMPR | up-regulates quantity
chemical modification
|
ammonium |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280513 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33369428 |
The human GMPR enzyme maintains the intracellular balance between the adenine and guanine nucleotide pools. The chemical reaction of this enzyme proceeds by deamination and hydride transfer steps. In deamination, the thiol group of Cys186 reacts on C2 of 5GP to form an intermediate E-XMP. In the second step, nicotinamide moves adjacent to C2 of E-XMP to allow hydride ion transfer, resulting in the production of inosine-5′-monophosphate (IMP) (Figure S4). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
GMPR
- 
- 