Relation Results

Name	GPX4
Full Name	Phospholipid hydroperoxide glutathione peroxidase
Synonyms	PHGPx, Glutathione peroxidase 4, GPx-4, GSHPx-4 \|
Primary ID	P36969
Links	- -
Type	protein
Relations	2
Function	Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity). Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (PubMed:24439385). The presence of selenocysteine (Sec) versus Cys at the active site is essential for life