4.0
Summary
| Name |  CCNFView Modifications |
| Full Name | Cyclin-F |
| Synonyms | F-box only protein 1 | FBX1, FBXO1 |
| Primary ID | P41002 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | AKT | up-regulates activity 
phosphorylation
|
CCNF | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | CSNK2A1 | down-regulates activity 
phosphorylation
|
CCNF | 0.248 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CCNF | down-regulates quantity by destabilization
ubiquitination
|
CCP110 | 0.528 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | APC-c | down-regulates quantity by destabilization
ubiquitination
|
CCNF | 0.482 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CCNF | down-regulates quantity by destabilization
ubiquitination
|
FZR1 | 0.555 |
| Publications: | 1 | Organism: | Homo Sapiens | |