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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png deacetylation AKT
Publications: 1 Organism: Mus Musculus
Tissue: Heart
Pathways:AMPK Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png desumoylation AKT
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png sumoylation AKT
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination AKT
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CDKN1B
Publications: 3 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition
+ up-regulates img/direct-activation.png phosphorylation YBX1
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ESR1
Publications: 4 Organism: Homo Sapiens
Pathways:Luminal Breast Cancer
+ up-regulates img/direct-activation.png phosphorylation H3F3A
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PALLD
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation FANCA
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PEA15
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NOS3
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD
Publications: 4 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis, Malignant Melanoma
+ img/unknown.png phosphorylation RANBP3
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation YAP1
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AKT
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png phosphorylation CREB1
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling, Inhibition of Apoptosis, Malignant Melanoma
+ up-regulates activity img/direct-activation.png phosphorylation CREB1
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling, Inhibition of Apoptosis, Malignant Melanoma
+ down-regulates img/direct_inhibition.png phosphorylation NR3C1
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MST1R
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CCDC88A
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ZYX
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DNMT1
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MXD1
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NCOR1
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation, binding CDKN1A
Publications: 3 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Rhabdomyosarcoma
+ down-regulates img/direct_inhibition.png phosphorylation GAB2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MDM2
Publications: 3 Organism: Homo Sapiens
Tissue: Kidney
Pathways:Acute Myeloid Leukemia, Cell cycle: G1/S phase transition, Luminal Breast Cancer, Malignant Melanoma, Prostate Cancer
+ up-regulates img/direct-activation.png phosphorylation EP300
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates activity img/direct-activation.png phosphorylation BAX
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation BAX
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation HMOX1
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation KHSRP
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CASP9
Publications: 2 Organism: In Vitro, Homo Sapiens
Pathways:Inhibition of Apoptosis
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO
Publications: 6 Organism: Mus Musculus, Homo Sapiens
Pathways:AML-BCRABL, AML-FLT3, PI3K/AKT
+ down-regulates img/direct_inhibition.png phosphorylation FOXO4
Publications: 4 Organism: Homo Sapiens
Pathways:Insulin Receptor
+ down-regulates img/direct_inhibition.png phosphorylation, relocalization FOXO
Publications: 10 Organism: Homo Sapiens, In Vitro, Mus Musculus
Pathways:AML-BCRABL, AML-FLT3, PI3K/AKT
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO4
Publications: 2 Organism: Mus Musculus
Pathways:Insulin Receptor
+ down-regulates img/direct_inhibition.png phosphorylation HNRNPA1
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GSK3A
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EZH2
Publications: 1 Organism: Homo Sapiens
Pathways:Prostate Cancer
+ down-regulates img/direct_inhibition.png phosphorylation HTRA2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation AR
Publications: 1 Organism: Homo Sapiens
Pathways:Prostate Cancer
+ up-regulates img/direct-activation.png phosphorylation TERT
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MTOR
Publications: 1 Organism: Homo Sapiens
Pathways:AML-BCRABL, AML-FLT3, AML-KIT, MTOR Signaling
+ up-regulates img/direct-activation.png phosphorylation TP53RK
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO3
Publications: 3
Pathways:AML-FLT3, AMPK Signaling, Insulin Receptor, Inhibition of Apoptosis, Thyroid cancer
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO3
Publications: 3 Organism: Homo Sapiens
Pathways:AML-FLT3, AMPK Signaling, Insulin Receptor, Inhibition of Apoptosis, Thyroid cancer
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO
Publications: 4 Organism: Homo Sapiens
Pathways:AML-BCRABL, AML-FLT3, PI3K/AKT
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO1
Publications: 6 Organism: In Vitro, Homo Sapiens, Mus Musculus
Pathways:FAP: Insulin-mediated adipogenesis, Insulin Receptor, Inhibition of Apoptosis, Rhabdomyosarcoma
+ down-regulates img/direct_inhibition.png phosphorylation RAF1
Publications: 3 Organism: Homo Sapiens
Tissue: Muscle, Myotube
Pathways:Insulin Receptor
+ img/unknown.png phosphorylation ARFIP2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CCT2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation METTL1
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png phosphorylation CFLAR
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CHEK1
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1C
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PHF20
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PDE3B
Publications: 2 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation PDE3B
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCF1
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SH3RF1
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PIKFYVE
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png phosphorylation GATA1
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BMI1
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CLK2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ADRB2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NR4A1
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation VCP
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BRAF
Publications: 3 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML-BCRABL, AML-FLT3, AML-KIT, EGFR, Inhibition of Apoptosis, Luminal Breast Cancer, Malignant Melanoma, PI3K/AKT, Rhabdomyosarcoma, Rtk signaling, Thyroid cancer, T cell activation
+ up-regulates img/direct-activation.png phosphorylation MDM4
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TTC3
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation VIM
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAP3K8
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MAP3K8
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GATA2
Publications: 1 Organism: Homo Sapiens
Pathways:FAP: Insulin-mediated adipogenesis
+ img/unknown.png phosphorylation HTT
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TWIST1
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EIF4B
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation ACLY
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates img/direct_inhibition.png phosphorylation PDCD4
Publications: 3 Organism: Homo Sapiens
Tissue: Skin
+ up-regulates img/direct-activation.png phosphorylation PFKFB3
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PFKFB2
Publications: 2 Organism: Homo Sapiens
Pathways:AMPK Signaling
+ up-regulates activity img/direct-activation.png phosphorylation PFKFB2
Publications: 4 Organism: Homo Sapiens
Tissue: Heart
Pathways:AMPK Signaling
+ up-regulates img/direct-activation.png phosphorylation AKT
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation AKT
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT
Publications: 3 Organism: Mus Musculus, Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation AKT
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation AKT
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png phosphorylation AKT
Publications: 3 Organism: Rattus Norvegicus, Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation AKT
Publications: 6 Organism: Homo Sapiens, Mus Musculus
Pathways:MTOR Signaling, PI3K/AKT
+ up-regulates activity img/direct-activation.png phosphorylation AKT
Publications: 2 Organism: Homo Sapiens
Pathways:AML-BCRABL, AML-FLT3, AML-KIT, MTOR Signaling
+ up-regulates img/direct-activation.png phosphorylation AKT
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation AKT
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PTPN1
Publications: 1 Organism: Mus Musculus
Pathways:Insulin Receptor
+ img/unknown.png phosphorylation CARHSP1
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png phosphorylation CTNNB1
Publications: 2 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma, Thyroid cancer
+ img/unknown.png phosphorylation ACAP1
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PPARGC1A
Publications: 1 Organism: Homo Sapiens
Tissue: Liver
Pathways:AMPK Signaling, MTOR Signaling
+ img/unknown.png phosphorylation YWHAZ
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation TBC1D4
Publications: 2 Organism: Mus Musculus, Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SH2B2
Publications: 1 Organism: Mus Musculus
+ img/unknown.png phosphorylation SH2B2
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation COPS6
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NUAK1
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation FAM129A
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation, binding NOS3
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ILF3
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAP3K11
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BRCA1
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RAC1
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TBX3
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation DLC1
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation ATXN1
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation AR
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:Prostate Cancer
+ down-regulates img/direct_inhibition.png phosphorylation MAP2K4
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR
+ down-regulates img/direct_inhibition.png phosphorylation HSPB1
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MAP3K5
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BCL2L11
Publications: 1 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation XIAP
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary Cancer Cell
Pathways:Inhibition of Apoptosis
+ down-regulates activity img/direct_inhibition.png phosphorylation GSK3B
Publications: 2 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Insulin Receptor, MTOR Signaling, PI3K/AKT
+ down-regulates img/direct_inhibition.png phosphorylation ZFP36L1
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TSC2
Publications: 2 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation RARA
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ up-regulates img/direct-activation.png phosphorylation AGAP2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation IRAK1
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation STK3
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation STK4
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png phosphorylation RNF11
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXA2
Publications: 1 Organism: Homo Sapiens
Pathways:FAP: Insulin-mediated adipogenesis
+ down-regulates img/direct_inhibition.png phosphorylation CDCA7
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PLN
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation ALYREF
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CHUK
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation POU5F1
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation S1PR1
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation AKT1S1
Publications: 1 Organism: Homo Sapiens
Pathways:MTOR Signaling
+ up-regulates activity img/direct-activation.png phosphorylation AKT
Publications: 5 Organism: Homo Sapiens, Rattus Norvegicus, Mus Musculus
Tissue: Muscle, Skeletal Muscle, Myotube, Brain
Pathways:Acute Myeloid Leukemia, AML-BCRABL, AML-FLT3, AML-KIT, AMPK Signaling, EGFR, FAP: Insulin-mediated adipogenesis, Insulin Receptor, Luminal Breast Cancer, mTOR cancer, Malignant Melanoma, MTOR Signaling, Prostate Cancer, PI3K/AKT, Rhabdomyosarcoma, Thyroid cancer, T cell activation
+ down-regulates img/direct_inhibition.png dephosphorylation AKT
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT
Publications: 1
+ down-regulates activity img/direct_inhibition.png phosphorylation AKT
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation PPP1CA
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ img/unknown.png phosphorylation LTB4R2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDK2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation AKT
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SKI
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SRPK2
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation EZR
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation WNK1
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ITGB3
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation TAL1
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT
Publications: 1 Organism: Mus Musculus
Tissue: Prostate Adenocarcinoma Cell
+ up-regulates img/direct-activation.png phosphorylation AKT
Publications: 2 Organism: Homo Sapiens
Pathways:Thyroid cancer
+ up-regulates img/direct-activation.png phosphorylation AKT
Publications: 3 Organism: Homo Sapiens
Tissue: Prostate Gland
+ up-regulates activity img/direct-activation.png phosphorylation AKT
Publications: 3 Organism: Homo Sapiens, Chlorocebus Aethiops
Pathways:EGFR, Rhabdomyosarcoma
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation AKT
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png unknown AKT
Publications: 1 Organism: Homo Sapiens
Tissue: Breast Cancer Cell
Pathways:Acute Myeloid Leukemia, AMPK Signaling, EGFR, Luminal Breast Cancer, mTOR cancer, Malignant Melanoma, MTOR Signaling, Prostate Cancer, Rhabdomyosarcoma
+ up-regulates img/indirect-activation.png unknown AKT
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization AKT
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AKT
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AKT
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown AKT
Publications: 1 Organism: Mus Musculus
Pathways:AMPK Signaling, FAP: Insulin-mediated adipogenesis, Insulin Receptor, mTOR cancer, MTOR Signaling
+ up-regulates activity img/indirect-activation.png unknown AKT
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML-FLT3
+ down-regulates img/indirect_inhibition.png unknown AKT
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png cleavage AKT
Publications: 1 Organism: In Vitro
Pathways:Inhibition of Apoptosis
+ down-regulates img/direct_inhibition.png phosphorylation TBC1D4
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates img/direct_inhibition.png phosphorylation FOXO6
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown SLC2A4
Publications: 2 Organism: Homo Sapiens
Pathways:Insulin Receptor
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SLC2A1
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding PHB2
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation DLX5
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AMPK Signaling, EGFR, Luminal Breast Cancer, mTOR cancer, Malignant Melanoma, MTOR Signaling, Prostate Cancer, Rhabdomyosarcoma
+ up-regulates img/indirect-activation.png unknown PRKACA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png unknown FAS
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png unknown AKT
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AKT
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png unknown AKT
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png unknown AKT
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png unknown AKT
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png unknown AKT
Publications: 2 Organism: Homo Sapiens
Pathways:Insulin Receptor, Luminal Breast Cancer, Malignant Melanoma, MTOR Signaling, Prostate Cancer, Thyroid cancer
+ down-regulates img/direct_inhibition.png binding SMAD3
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Thyroid cancer
+ down-regulates activity img/direct_inhibition.png unknown AKT
Publications: 1 Organism: Homo Sapiens
Pathways:Prostate Cancer
+ up-regulates img/indirect-activation.png unknown Survival
Publications: 2 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis, Luminal Breast Cancer, Malignant Melanoma, Prostate Cancer, Rhabdomyosarcoma, Thyroid cancer
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CTNNB1
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma, Thyroid cancer
+ up-regulates activity img/indirect-activation.png unknown AKT
Publications: 2 Organism: Homo Sapiens
Tissue: Breast Cancer Cell
Pathways:AML-BCRABL, AML-FLT3, AML-KIT, FAP: Insulin-mediated adipogenesis, mTOR cancer, PI3K/AKT, Rtk signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination AKT
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/indirect_inhibition.png unknown AKT
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:Cell cycle: G1/S phase transition
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TSC1/TSC2
Publications: 1 Organism: Mus Musculus
Pathways:AMPK Signaling, Insulin Receptor, Luminal Breast Cancer, mTOR cancer, MTOR Signaling
+ up-regulates activity img/indirect-activation.png unknown AKT
Publications: 1 Organism: Mus Musculus
Pathways:Rhabdomyosarcoma
+ up-regulates activity img/direct-activation.png relocalization AKT
Publications: 1 Organism: Homo Sapiens
Tissue: Prostate Gland Cancer Cell
Pathways:Acute Myeloid Leukemia, AML-BCRABL, AMPK Signaling, EGFR, FAP: Insulin-mediated adipogenesis, Insulin Receptor, Luminal Breast Cancer, Malignant Melanoma, MTOR Signaling, Prostate Cancer, Rhabdomyosarcoma, Thyroid cancer, T cell activation
+ down-regulates activity img/direct_inhibition.png cleavage AKT
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation AKT
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AKT
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AKT
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding AKT
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown MTOR
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:AML-BCRABL, AML-FLT3, AML-KIT, MTOR Signaling
+ up-regulates img/indirect-activation.png unknown MEF2D
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates activity img/indirect-activation.png unknown AKT
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Rtk signaling
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AKT
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png unknown AKT
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown AKT
Publications: 1 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis
+ down-regulates img/direct_inhibition.png binding AKT
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding AKT
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding AKT
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown AKT
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png phosphorylation IKK-complex
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Inhibition of Apoptosis, T cell activation
+ down-regulates activity img/indirect_inhibition.png unknown MAPK14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png unknown AKT
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation GSK3B
Publications: 1
Pathways:Cell cycle: G1/S phase transition, Insulin Receptor, MTOR Signaling, PI3K/AKT
+ up-regulates img/direct-activation.png relocalization AKT
Publications: 1 Organism: Rattus Norvegicus
Pathways:Acute Myeloid Leukemia, AML-BCRABL, AMPK Signaling, EGFR, FAP: Insulin-mediated adipogenesis, Insulin Receptor, Luminal Breast Cancer, Malignant Melanoma, MTOR Signaling, Prostate Cancer, Rhabdomyosarcoma, Thyroid cancer, T cell activation
+ down-regulates img/direct_inhibition.png phosphorylation FOXA2
Publications: 1 Organism: Homo Sapiens
Pathways:FAP: Insulin-mediated adipogenesis
+ up-regulates activity img/direct-activation.png phosphorylation AKT
Publications: 1 Organism: Homo Sapiens
Pathways:AML-BCRABL, AML-FLT3, AML-KIT, FAP: Insulin-mediated adipogenesis, mTOR cancer, PI3K/AKT, Rtk signaling
+ down-regulates activity img/direct_inhibition.png binding AKT
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding HK1
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation mTORC1
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Tissue: Muscle, Skeletal Muscle, Myotube
Pathways:AMPK Signaling, Insulin Receptor, Luminal Breast Cancer, PI3K/AKT
+ down-regulates img/direct_inhibition.png binding CDKN1B
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition
+ up-regulates img/direct-activation.png phosphorylation SP7
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AKT
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding AKT
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding AKT
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML-FLT3
+ down-regulates activity img/indirect_inhibition.png unknown INSIG2
Publications: 1 Organism: Mus Musculus
Tissue: Liver
+ up-regulates img/indirect-activation.png unknown AKT
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png relocalization FOXO1
Publications: 1 Organism: Mus Musculus
Pathways:FAP: Insulin-mediated adipogenesis, Insulin Receptor, Inhibition of Apoptosis, Rhabdomyosarcoma
+ down-regulates activity img/direct_inhibition.png phosphorylation PRKAA1
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination AKT
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/indirect-activation.png relocalization AKT
Publications: 1 Organism: Homo Sapiens
Tissue: Breast Cancer Cell
Pathways:Acute Myeloid Leukemia, AML-BCRABL, AMPK Signaling, EGFR, FAP: Insulin-mediated adipogenesis, Insulin Receptor, Luminal Breast Cancer, Malignant Melanoma, MTOR Signaling, Prostate Cancer, Rhabdomyosarcoma, Thyroid cancer, T cell activation
+ down-regulates activity img/direct_inhibition.png binding AKT
Publications: 1 Organism: Homo Sapiens
Tissue: Liver
+ up-regulates img/indirect-activation.png unknown AKT
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png unknown AKT
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation AKT
Publications: 1 Organism: Homo Sapiens
Pathways:Insulin Receptor
+ down-regulates img/direct_inhibition.png dephosphorylation AKT
Publications: 1 Organism: Homo Sapiens