4.0
Summary
| Name |  APOBEC1
|
| Full Name | C->U-editing enzyme APOBEC-1 |
| Synonyms | Apolipoprotein B mRNA-editing enzyme catalytic subunit 1, APO1, APOBEC-1, Apolipoprotein B mRNA-editing enzyme 1, 3.5.4.36, HEPR, mRNA(cytosine(6666)) deaminase 1 | |
| Primary ID | P41238 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Cytidine deaminase catalyzing the cytidine to uridine postranscriptional editing of a variety of mRNAs (PubMed:30844405). Form complexes with cofactors that confer differential editing activity and selectivity. Responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the apolipoprotein B mRNA (PubMed:24916387). Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA (PubMed:11727199). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (By similarity). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | APOBEC1 | form complex 
binding
|
C-to-U editosome complex | |
| Publications: | 1 | Organism: | Homo Sapiens | |