Summary

Name GRIA3
Full Name Glutamate receptor 3
Synonyms GluR-3, AMPA-selective glutamate receptor 3, GluR-C, GluR-K3, Glutamate receptor ionotropic, AMPA 3, GluA3 | GLUR3, GLURC
Primary ID P42263
Links - -
Type protein
Relations 5
Function Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

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Relations

Regulator Mechanism target score ℹ
+ GRIA3up-regulates quantity img/direct-activation.png relocalization calcium(2+) 0.8
Publications: 1 Organism: Homo Sapiens
+ SHANK3up-regulates quantity img/direct-activation.png binding GRIA3 0.2
Publications: 1 Organism: Homo Sapiens
+ glutamic acidup-regulates activity img/direct-activation.png chemical activation GRIA3 0.8
Publications: 1 Organism: Homo Sapiens
+ GRIA3up-regulates img/indirect-activation.png Excitatory_synaptic_transmission 0.7
Publications: 1 Organism: Homo Sapiens
+ IQSEC2up-regulates quantity img/direct-activation.png relocalization GRIA3 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Brain