Summary

Name CTSK
Full Name Cathepsin K
Synonyms Cathepsin O, Cathepsin O2, Cathepsin X | CTSO, CTSO2
Primary ID P43235
Links - -
Type protein
Relations 4
Inhibitors Odanacatib
Function Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:11082042).

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Relations

Regulator Mechanism target score
+ up-regulates img/indirect-activation.png ECM_disassembly 0.7
Publications: 1
+ down-regulates img/direct_inhibition.png chemical inhibition CTSK 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CTSK 0.343
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CTSK 0.371
Publications: 1