| + |
TNF | up-regulates quantity by expression
transcriptional regulation
|
CTSK |
0.36 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253317 |
|
|
|
|
| pmid |
sentence |
| 11920402 |
This is supported by our finding that inflammatory cytokines such as IL-1b and TNFa increase the expres- sion of cathepsin K mRNA 6–8-fold and increase the secretion of the mature enzyme. |
|
| Publications: |
1 |
| + |
CTSK | up-regulates
|
ECM_disassembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253318 |
|
|
|
|
| pmid |
sentence |
| 11920402 |
Cathepsins K and S have been implicated in various aspects of extracellular matrix degradation and inflammatory responses. |
|
| Publications: |
1 |
| + |
Odanacatib | down-regulates
chemical inhibition
|
CTSK |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195007 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1B | up-regulates quantity by expression
transcriptional regulation
|
CTSK |
0.334 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253316 |
|
|
|
|
| pmid |
sentence |
| 11920402 |
This is supported by our finding that inflammatory cytokines such as IL-1b and TNFa increase the expres- sion of cathepsin K mRNA 6–8-fold and increase the secretion of the mature enzyme. |
|
| Publications: |
1 |