4.0
Summary
| Name |  IER3View Modifications |
| Full Name | Radiation-inducible immediate-early gene IEX-1 |
| Synonyms | Differentiation-dependent gene 2 protein, Protein DIF-2, Immediate early protein GLY96, Immediate early response 3 protein, PACAP-responsive gene 1 protein, Protein PRG1 | DIF2, IEX1, PRG1 |
| Primary ID | P46695 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAPK1 | up-regulates 
phosphorylation
|
IER3 | 0.553 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MDM2 | down-regulates quantity by destabilization 
ubiquitination
|
IER3 | 0.348 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | IER3 | down-regulates
binding
|
PPP2R5C | 0.543 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HNRNPU | up-regulates quantity by stabilization 
post transcriptional regulation
|
IER3 | 0.2 |
| Publications: | 1 | |||