Summary

Name MAPK1
Full Name Mitogen-activated protein kinase 1
Synonyms MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2 | ERK2, PRKM1, PRKM2
Primary ID P28482
Links - -
Type protein
Relations 528
Pathways Glucocorticoid receptor Signaling, Nucleotide Biosynthesis
Inhibitors 4-[2-(2-chloro-4-fluoroanilino)-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in respons to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2 (By similarity).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation CDKN1B 0.35
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation JUND 0.542
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CDC42EP2 0.249
Publications: 1 Organism: Mus Musculus
+ img/unknown.png phosphorylation HNRNPH1 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation ESR1 0.657
Publications: 6 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation LIFR 0.377
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation POU5F1 0.385
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PPARG 0.468
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ESPL1 0.281
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CDC42EP1 0.2
Publications: 2 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation SOS1 0.702
Publications: 6 Organism: Chlorocebus Aethiops, Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SREBF1 0.415
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCOA1 0.372
Publications: 3 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ up-regulates activity img/direct-activation.png phosphorylation PPARA 0.562
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NR4A2 0.401
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CDKN1A 0.368
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ETV3 0.41
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation MAFA 0.342
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CIC 0.378
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation THRB 0.392
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TFEB 0.42
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation TAGLN2 0.272
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PPP1R9B 0.474
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GRB10 0.381
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RGS19 0.486
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BRAF 0.614
Publications: 2 Organism: Homo Sapiens, Rattus Norvegicus
+ down-regulates img/direct_inhibition.png phosphorylation TOB1 0.362
Publications: 3 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation DUSP6 0.902
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ATP1A1 0.511
Publications: 1 Organism: Mycolicibacterium Chitae
+ down-regulates activity img/direct_inhibition.png phosphorylation TPPP 0.359
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation ERF 0.581
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation POLR2A 0.316
Publications: 23 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTTG1 0.361
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RCAN1 0.272
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation PCBP2 0.324
Publications: 4 Organism: Homo Sapiens
+ img/unknown.png phosphorylation APBB1 0.26
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MITF 0.692
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ABI1 0.422
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD1 0.593
Publications: 8 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PAX5 0.359
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NR5A1 0.473
Publications: 1 Organism: Chlorocebus Aethiops
+ img/unknown.png phosphorylation SMAD3 0.735
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SMAD3 0.735
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SMAD1 0.593
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CEBPA 0.357
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MCRIP1 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD3 0.735
Publications: 4 Organism: Homo Sapiens
Tissue: Lung, Breast
+ down-regulates img/direct_inhibition.png phosphorylation ETV6 0.322
Publications: 2 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation TPR 0.383
Publications: 4 Organism: Homo Sapiens
+ img/unknown.png phosphorylation AHNAK 0.258
Publications: 5 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation NUP50 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KA1 0.754
Publications: 8 Organism: Chlorocebus Aethiops, Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPS6K 0.757
Publications: 8 Organism: Chlorocebus Aethiops, Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SPHK1 0.545
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NR3C1 0.608
Publications: 1 Organism: In Vitro
Pathways:Glucocorticoid receptor Signaling
+ up-regulates img/direct-activation.png phosphorylation EP300 0.477
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation ZFP36 0.468
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation NDE1 0.383
Publications: 3 Organism: Homo Sapiens, In Vitro
+ up-regulates img/direct-activation.png phosphorylation SMAD2 0.711
Publications: 4 Organism: Homo Sapiens
Tissue: Lung
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation RUNX1 0.2
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RUNX1 0.2
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EXOC7 0.334
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GJA1 0.596
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RXRA 0.517
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ALOX5 0.386
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPKAPK2 0.522
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GORASP1 0.272
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png phosphorylation TNFRSF1A 0.513
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation CIITA 0.441
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NOXA1 0.332
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CIITA 0.441
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RAF1 0.618
Publications: 6 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation TFCP2 0.342
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation AMPH 0.268
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PGR 0.59
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO3 0.708
Publications: 3 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO 0.708
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation AMPH 0.268
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation DUSP1 0.797
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation GIGYF2 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation IRS1 0.667
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PCYT1A 0.433
Publications: 1 Organism: Homo Sapiens
Tissue: Lung
+ up-regulates activity img/direct-activation.png phosphorylation ELK1 0.548
Publications: 4 Organism: Mus Musculus
+ img/unknown.png phosphorylation NID1 0.252
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation BCL6 0.501
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PPP2R5C 0.495
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCF1 0.458
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DUSP1 0.797
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PML 0.367
Publications: 6 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6KA5 0.604
Publications: 5 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates activity img/direct-activation.png phosphorylation FOS 0.783
Publications: 7 Organism: , Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation LIMA1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CSNK2A1 0.378
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ASB2 0.268
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation PARP1 0.531
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KA5 0.604
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation STMN1 0.432
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GAB1 0.586
Publications: 6 Organism: Cricetulus Griseus
+ up-regulates img/direct-activation.png phosphorylation SPHK2 0.432
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CASP8 0.747
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates activity img/direct-activation.png phosphorylation PARVA 0.262
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CTTN 0.477
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ARRB1 0.716
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation XPO5 0.306
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation GRB10 0.381
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation CEP55 0.374
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation STK11 0.412
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation METTL3 0.277
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SREBF2 0.366
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation KRT8 0.39
Publications: 1
+ img/unknown.png phosphorylation GABRR1 0.291
Publications: 3 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation RPS6KB1 0.58
Publications: 10 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:Nucleotide Biosynthesis
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation DUSP16 0.8
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png phosphorylation MRTFA 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation IRX2 0.2
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation KLC1 0.274
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CAPN2 0.614
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PLA2G4A 0.642
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation AR 0.523
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation DYNC1LI1 0.257
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation NEFH 0.376
Publications: 3 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png phosphorylation MAPT 0.549
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation JAK2 0.493
Publications: 1 Organism: Chlorocebus Aethiops
+ img/unknown.png phosphorylation NUP153 0.398
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SORBS3 0.396
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation MYB 0.49
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation TSC2 0.668
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation NOX5 0.33
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation WWC1 0.271
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates img/direct-activation.png phosphorylation STIM1 0.355
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PDE4D (isoform 2) 0.358
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation KHDRBS1 0.653
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LCK 0.567
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ up-regulates img/direct-activation.png phosphorylation SP1 0.63
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation KCND2 0.371
Publications: 3 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.667
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MYC 0.723
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:Nucleotide Biosynthesis
+ up-regulates img/direct-activation.png phosphorylation TH 0.451
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GAB2 0.667
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PDE4C 0.257
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HIF1A 0.572
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EIF4EBP1 0.649
Publications: 5 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TSC2 0.668
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GTF2I 0.372
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NFATC4 0.285
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TWIST1 0.307
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation STMN3 0.2
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation ARHGAP26 0.2
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation BCL2L11 0.703
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RPTOR 0.53
Publications: 3 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation BCL2 0.535
Publications: 5 Organism: Homo Sapiens, Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png phosphorylation PDE4D 0.359
Publications: 4 Organism: Homo Sapiens
+ img/unknown.png phosphorylation DDHD1 0.2
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation SP3 0.309
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DAPK1 0.553
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BMF 0.254
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CALD1 0.522
Publications: 2 Organism: Homo Sapiens
Tissue: Smooth Muscle
+ up-regulates img/direct-activation.png phosphorylation SLC9A1 0.659
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FGFR1 0.313
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT5A 0.75
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
Pathways:Glucocorticoid receptor Signaling
+ up-regulates activity img/direct-activation.png phosphorylation TP53BP2 0.265
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation IL16 0.267
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPTOR 0.53
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation DYNC1I2 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation NCOA6 0.2
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation GSK3B 0.392
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation PTPN7 0.805
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PLCB1 0.407
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation TNKS1BP1 0.2
Publications: 2 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation MED1 0.358
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation UBTF 0.403
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PITPNM1 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CASP9 0.547
Publications: 2 Organism: Homo Sapiens, Mus Musculus
+ img/unknown.png phosphorylation MYO9B 0.307
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation NR4A1 0.659
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation CDK2 0.478
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MCL1 0.54
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRDX6 0.681
Publications: 1 Organism: Homo Sapiens
Tissue: Lung
+ img/unknown.png phosphorylation DOCK1 0.253
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation IER3 0.535
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPKAPK5 0.494
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RORA 0.262
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPK1 0.743
Publications: 4 Organism: Homo Sapiens, Mus Musculus
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK1 0.606
Publications: 2 Organism: Homo Sapiens, Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK1 0.459
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation MAPK1 0.737
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPK1 0.2
Publications: 4 Organism: Homo Sapiens, Mus Musculus
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK1 0.752
Publications: 2 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK1 0.797
Publications: 2 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK1 0.4
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK1 0.606
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPK1 0.2
Publications: 2
Pathways:Glucocorticoid receptor Signaling, Nucleotide Biosynthesis
+ down-regulates activity img/direct_inhibition.png phosphorylation PAK1 0.413
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png phosphorylation NDEL1 0.289
Publications: 2 Organism: In Vitro
+ img/unknown.png phosphorylation GORASP2 0.639
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation MBP 0.567
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MBP 0.567
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.705
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RSPH3 0.2
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RAI14 0.27
Publications: 1 Organism: Mus Musculus
+ img/unknown.png phosphorylation AKAP4 0.262
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation DAZAP1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SMAD4 0.523
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MAP2K1 0.743
Publications: 2 Organism: Chlorocebus Aethiops, Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ELK1 0.548
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation TCF3 0.368
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation PTPRR 0.818
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation RPS3 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RPS3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GSK3B 0.392
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EIF4EBP1 0.649
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EIF2AK2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CAD 0.391
Publications: 1 Organism: Homo Sapiens
Pathways:Nucleotide Biosynthesis
+ down-regulates img/direct_inhibition.png phosphorylation ERF 0.581
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SCNN1B 0.295
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation PFAS 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Nucleotide Biosynthesis
+ up-regulates activity img/direct-activation.png phosphorylation AEBP1 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SCNN1G 0.368
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation ARHGEF2 0.366
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.723
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PDXDC1 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation EGFR 0.625
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation RBFOX2 0.2
Publications: 1 Organism: Mus Musculus
+ img/unknown.png phosphorylation EWSR1 0.25
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation UBAP2L 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation LIPE 0.376
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK1 0.417
Publications: 2 Organism: In Vitro, Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK1 0.66
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK1 0.818
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation MAPK1 0.434
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK1 0.805
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK1 0.417
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.438
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK1 0.752
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png SLC2A4 0.338
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD2 0.711
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MAPK1 0.553
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK1 0.805
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation mTORC1 0.384
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png relocalization, phosphorylation PPARG 0.468
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAP3K5 0.324
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MKNK1 0.579
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TSC1 0.468
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PDE4D 0.359
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation MAPK1 0.8
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ down-regulates activity img/direct_inhibition.png phosphorylation MEK1/2 0.748
Publications: 2 Organism: Chlorocebus Aethiops, Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GSK3B/Axin/APC 0.325
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK1 0.791
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ down-regulates img/direct_inhibition.png binding, dephosphorylation MAPK1 0.689
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CyclinE/CDK2 0.388
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png MAPK14 0.492
Publications: 2 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK1 0.735
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png MAPK1 0.864
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png MAPK1 0.397
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition MAPK1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RAF1 0.618
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation THR 0.425
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK1 0.392
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6KA3 0.72
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK1 0.457
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6KA2 0.709
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MKNK2 0.586
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAPK1 0.567
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ up-regulates activity img/direct-activation.png phosphorylation JUN 0.781
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK1 0.902
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK1 0.797
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK1 0.772
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MAPK1 0.495
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAPK1 0.52
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png MAPK1 0.608
Publications: 1 Organism: Mus Musculus
Pathways:Glucocorticoid receptor Signaling
+ up-regulates activity img/indirect-activation.png MAPK1 0.701
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation MAPK1 0.737
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png MAPK1 0.595
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation LRP6 0.304
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPK1 0.487
Publications: 1 Organism: Homo Sapiens