Summary

Name MAP1B
Full Name Microtubule-associated protein 1B
Synonyms MAP-1B
Primary ID P46821
Links - -
Type protein
Relations 4
Function Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding MAP1B 0.265
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding Microtubule_polimerization 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MAP1B 0.543
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png ubiquitination MAP1B 0.257
Publications: 1 Organism: Mus Musculus