| + |
SLC6A8 | up-regulates quantity 
relocalization
|
creatine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265808 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18652074 |
CRT is essential for normal brain function as mutations in the CRT gene (SLC6A8) result in X-linked mental retardation, associated with the almost complete lack of creatine in the brain, severe speech and language delay, epilepsy, and autistic behaviour. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265782 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18652074 |
CRT is essential for normal brain function as mutations in the CRT gene (SLC6A8) result in X-linked mental retardation, associated with the almost complete lack of creatine in the brain, severe speech and language delay, epilepsy, and autistic behaviour. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
JAK2 | down-regulates activity 
relocalization
|
SLC6A8 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265807 |
|
|
Xenopus laevis laevis |
Oocyte |
| pmid |
sentence |
| 22407360 |
Janus-activated kinase-2 (JAK2) participates in the regulation of the Na⁺-coupled glucose transporter SGLT1 and the Na⁺-coupled amino acid transporter SLC6A19. JAK2 is a novel regulator of the creatine transporter SLC6A8, which downregulates the carrier, presumably by interference with carrier protein insertion into the cell membrane. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265781 |
|
|
Xenopus laevis laevis |
Oocyte |
| pmid |
sentence |
| 22407360 |
Janus-activated kinase-2 (JAK2) participates in the regulation of the Na⁺-coupled glucose transporter SGLT1 and the Na⁺-coupled amino acid transporter SLC6A19. JAK2 is a novel regulator of the creatine transporter SLC6A8, which downregulates the carrier, presumably by interference with carrier protein insertion into the cell membrane. |
|
| Publications: |
2 |
Organism: |
Xenopus Laevis Laevis |
3.0
SLC6A8
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