| + |
RFX5 | up-regulates quantity by expression 
transcriptional regulation
|
HLA-DRA |
0.518 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266228 |
|
|
Homo sapiens |
Fibrosarcoma Cell Line |
| pmid |
sentence |
| 10586057 |
In this report, we correlate the loss of IFN-γ induction of MHC class II genes with the identification of a molecular defect in an essential regulator, namely RFX5. | We have further confirmed this finding by showing that new RFX5 leucine mutants created in vitro are incapable of transactivating a class II promoter, suggesting the identification of residues essential for RFX activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IFNG | up-regulates activity 
|
RFX5 |
0.287 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241368 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9177217 |
Transcriptional Activation by the RFX5 Activation Domain Is IFN-_-Inducible in HeLa Cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RFX5 | form complex 
binding
|
RFX complex |
0.893 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-221565 |
|
|
in vitro |
|
| pmid |
sentence |
| 10825209 |
RFXANK and RFXAP bind to each other and form a heterodimer (step 1) that subsequently interacts with RFX5 Upon binding, the conformation of RFX5 changes (step 2) in a way that enables the RFX complex to bind to DNA (step 3) and to recruit other proteins that are required for the transcription of MHC II genes |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CIITA | up-regulates activity
binding
|
RFX5 |
0.755 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240980 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 9177217 |
RFX5 can activate transcription only in cooperation with CIITA. RFX5 and CIITA associate to form a complex capable of activating transcription from class II major histocompatibility complex promoters. In this complex, promoter specificity is determined by the DNA binding domain of RFX5 and the general transcription apparatus is recruited by the acidic activation domain of CIITA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
RFX5
- 
- 