| + |
RFXAP | form complex 
binding
|
RFX complex |
0.82 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-221568 |
|
|
in vitro |
|
| pmid |
sentence |
| 10825209 |
RFXANK and RFXAP bind to each other and form a heterodimer (step 1) that subsequently interacts with RFX5 Upon binding, the conformation of RFX5 changes (step 2) in a way that enables the RFX complex to bind to DNA (step 3) and to recruit other proteins that are required for the transcription of MHC II genes |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
RFX complex | up-regulates quantity by expression 
transcriptional regulation
|
HLA-DQB2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253997 |
|
|
in vitro |
|
| pmid |
sentence |
| 11258423 |
The RFX complex is comprised of three proteins – RFX5, RFXB, and RFXAP – all of which are required for expression of MHCII genes|In our current studies, we have utilized electrophoretic mobility shift assays to characterize the DNA binding of the RFX5(1–330)2•RFXAP•RFXB complex to the proximal regulatory region from the HLA-DRα gene to gain insight into the DNA binding properties of the RFX complex |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
RFX complex | up-regulates quantity by expression
transcriptional regulation
|
HLA-DRB5 |
0.282 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254003 |
|
|
in vitro |
|
| pmid |
sentence |
| 11258423 |
The RFX complex is comprised of three proteins – RFX5, RFXB, and RFXAP – all of which are required for expression of MHCII genes|In our current studies, we have utilized electrophoretic mobility shift assays to characterize the DNA binding of the RFX5(1–330)2•RFXAP•RFXB complex to the proximal regulatory region from the HLA-DRα gene to gain insight into the DNA binding properties of the RFX complex |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
RFX complex | up-regulates quantity by expression
transcriptional regulation
|
HLA-DQB1 |
0.272 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253992 |
|
|
in vitro |
|
| pmid |
sentence |
| 11258423 |
The RFX complex is comprised of three proteins – RFX5, RFXB, and RFXAP – all of which are required for expression of MHCII genes|In our current studies, we have utilized electrophoretic mobility shift assays to characterize the DNA binding of the RFX5(1–330)2•RFXAP•RFXB complex to the proximal regulatory region from the HLA-DRα gene to gain insight into the DNA binding properties of the RFX complex |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
RFX complex | up-regulates quantity by expression
transcriptional regulation
|
HLA-DPA1 |
0.262 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253995 |
|
|
in vitro |
|
| pmid |
sentence |
| 11258423 |
The RFX complex is comprised of three proteins – RFX5, RFXB, and RFXAP – all of which are required for expression of MHCII genes|In our current studies, we have utilized electrophoretic mobility shift assays to characterize the DNA binding of the RFX5(1–330)2•RFXAP•RFXB complex to the proximal regulatory region from the HLA-DRα gene to gain insight into the DNA binding properties of the RFX complex |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
RFX complex | up-regulates quantity by expression
transcriptional regulation
|
HLA-DPB1 |
0.285 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253990 |
|
|
in vitro |
|
| pmid |
sentence |
| 11258423 |
The RFX complex is comprised of three proteins – RFX5, RFXB, and RFXAP – all of which are required for expression of MHCII genes|In our current studies, we have utilized electrophoretic mobility shift assays to characterize the DNA binding of the RFX5(1–330)2•RFXAP•RFXB complex to the proximal regulatory region from the HLA-DRα gene to gain insight into the DNA binding properties of the RFX complex |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254007 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 11889043 |
Promoter-specific functions of CIITA and the MHC class II enhanceosome in transcriptional activation|We compared four genes co-regulated by RFX and CIITA (HLA-DRA, HLA-DPB, HLA-DMB and Ii) and found that the enhanceosome and CIITA make variable, promoter-dependent contributions to histone acetylation and transcription apparatus recruitment. |
|
| Publications: |
2 |
Organism: |
In Vitro, Homo Sapiens |
| + |
RFX complex | up-regulates quantity by expression
transcriptional regulation
|
HLA-DOA |
0.325 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253994 |
|
|
in vitro |
|
| pmid |
sentence |
| 11258423 |
The RFX complex is comprised of three proteins – RFX5, RFXB, and RFXAP – all of which are required for expression of MHCII genes|In our current studies, we have utilized electrophoretic mobility shift assays to characterize the DNA binding of the RFX5(1–330)2•RFXAP•RFXB complex to the proximal regulatory region from the HLA-DRα gene to gain insight into the DNA binding properties of the RFX complex |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
RFX complex | up-regulates quantity by expression
transcriptional regulation
|
HLA-DQA2 |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253996 |
|
|
in vitro |
|
| pmid |
sentence |
| 11258423 |
The RFX complex is comprised of three proteins – RFX5, RFXB, and RFXAP – all of which are required for expression of MHCII genes|In our current studies, we have utilized electrophoretic mobility shift assays to characterize the DNA binding of the RFX5(1–330)2•RFXAP•RFXB complex to the proximal regulatory region from the HLA-DRα gene to gain insight into the DNA binding properties of the RFX complex |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
RFX complex | up-regulates quantity by expression
transcriptional regulation
|
HLA-DMB |
0.36 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254016 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 11889043 |
Promoter-specific functions of CIITA and the MHC class II enhanceosome in transcriptional activation|We compared four genes co-regulated by RFX and CIITA (HLA-DRA, HLA-DPB, HLA-DMB and Ii) and found that the enhanceosome and CIITA make variable, promoter-dependent contributions to histone acetylation and transcription apparatus recruitment. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253999 |
|
|
in vitro |
|
| pmid |
sentence |
| 11258423 |
The RFX complex is comprised of three proteins – RFX5, RFXB, and RFXAP – all of which are required for expression of MHCII genes|In our current studies, we have utilized electrophoretic mobility shift assays to characterize the DNA binding of the RFX5(1–330)2•RFXAP•RFXB complex to the proximal regulatory region from the HLA-DRα gene to gain insight into the DNA binding properties of the RFX complex |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, In Vitro |
| + |
RFX complex | up-regulates quantity by expression
transcriptional regulation
|
HLA-DRA |
0.408 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253998 |
|
|
in vitro |
|
| pmid |
sentence |
| 11258423 |
The RFX complex is comprised of three proteins – RFX5, RFXB, and RFXAP – all of which are required for expression of MHCII genes|In our current studies, we have utilized electrophoretic mobility shift assays to characterize the DNA binding of the RFX5(1–330)2•RFXAP•RFXB complex to the proximal regulatory region from the HLA-DRα gene to gain insight into the DNA binding properties of the RFX complex |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254009 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 11889043 |
Promoter-specific functions of CIITA and the MHC class II enhanceosome in transcriptional activation|We compared four genes co-regulated by RFX and CIITA (HLA-DRA, HLA-DPB, HLA-DMB and Ii) and found that the enhanceosome and CIITA make variable, promoter-dependent contributions to histone acetylation and transcription apparatus recruitment. |
|
| Publications: |
2 |
Organism: |
In Vitro, Homo Sapiens |
| + |
RFX5 | form complex
binding
|
RFX complex |
0.892 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-221565 |
|
|
in vitro |
|
| pmid |
sentence |
| 10825209 |
RFXANK and RFXAP bind to each other and form a heterodimer (step 1) that subsequently interacts with RFX5 Upon binding, the conformation of RFX5 changes (step 2) in a way that enables the RFX complex to bind to DNA (step 3) and to recruit other proteins that are required for the transcription of MHC II genes |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
RFX complex | up-regulates quantity by expression
transcriptional regulation
|
HLA-DOB |
0.256 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254000 |
|
|
in vitro |
|
| pmid |
sentence |
| 11258423 |
The RFX complex is comprised of three proteins – RFX5, RFXB, and RFXAP – all of which are required for expression of MHCII genes|In our current studies, we have utilized electrophoretic mobility shift assays to characterize the DNA binding of the RFX5(1–330)2•RFXAP•RFXB complex to the proximal regulatory region from the HLA-DRα gene to gain insight into the DNA binding properties of the RFX complex |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
RFX complex | up-regulates quantity by expression
transcriptional regulation
|
HLA-DRB3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254001 |
|
|
in vitro |
|
| pmid |
sentence |
| 11258423 |
The RFX complex is comprised of three proteins – RFX5, RFXB, and RFXAP – all of which are required for expression of MHCII genes|In our current studies, we have utilized electrophoretic mobility shift assays to characterize the DNA binding of the RFX5(1–330)2•RFXAP•RFXB complex to the proximal regulatory region from the HLA-DRα gene to gain insight into the DNA binding properties of the RFX complex |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
RFX complex | up-regulates quantity by expression
transcriptional regulation
|
HLA-DMA |
0.325 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253993 |
|
|
in vitro |
|
| pmid |
sentence |
| 11258423 |
The RFX complex is comprised of three proteins – RFX5, RFXB, and RFXAP – all of which are required for expression of MHCII genes|In our current studies, we have utilized electrophoretic mobility shift assays to characterize the DNA binding of the RFX5(1–330)2•RFXAP•RFXB complex to the proximal regulatory region from the HLA-DRα gene to gain insight into the DNA binding properties of the RFX complex |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
RFXANK | form complex
binding
|
RFX complex |
0.817 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-221571 |
|
|
in vitro |
|
| pmid |
sentence |
| 10825209 |
RFXANK and RFXAP bind to each other and form a heterodimer (step 1) that subsequently interacts with RFX5 Upon binding, the conformation of RFX5 changes (step 2) in a way that enables the RFX complex to bind to DNA (step 3) and to recruit other proteins that are required for the transcription of MHC II genes |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
RFX complex | up-regulates quantity by expression
transcriptional regulation
|
HLA-DRB4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254002 |
|
|
in vitro |
|
| pmid |
sentence |
| 11258423 |
The RFX complex is comprised of three proteins – RFX5, RFXB, and RFXAP – all of which are required for expression of MHCII genes|In our current studies, we have utilized electrophoretic mobility shift assays to characterize the DNA binding of the RFX5(1–330)2•RFXAP•RFXB complex to the proximal regulatory region from the HLA-DRα gene to gain insight into the DNA binding properties of the RFX complex |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
RFX complex | up-regulates quantity by expression
transcriptional regulation
|
HLA-DQA1 |
0.283 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253991 |
|
|
in vitro |
|
| pmid |
sentence |
| 11258423 |
The RFX complex is comprised of three proteins – RFX5, RFXB, and RFXAP – all of which are required for expression of MHCII genes|In our current studies, we have utilized electrophoretic mobility shift assays to characterize the DNA binding of the RFX5(1–330)2•RFXAP•RFXB complex to the proximal regulatory region from the HLA-DRα gene to gain insight into the DNA binding properties of the RFX complex |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
RFX complex | up-regulates quantity by expression 
transcriptional regulation
|
HLA-DRB1 |
0.282 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253977 |
|
|
in vitro |
|
| pmid |
sentence |
| 11258423 |
The RFX complex is comprised of three proteins – RFX5, RFXB, and RFXAP – all of which are required for expression of MHCII genes|In our current studies, we have utilized electrophoretic mobility shift assays to characterize the DNA binding of the RFX5(1–330)2•RFXAP•RFXB complex to the proximal regulatory region from the HLA-DRα gene to gain insight into the DNA binding properties of the RFX complex |
|
| Publications: |
1 |
Organism: |
In Vitro |
4.0
RFX complex
CPX-6461