Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration.
This approach led us to the discovery that CD97, a pro-metastatic adhesion G-protein coupled receptor (GPCR), is a direct target of miR-126.| These results confirm the binding site for miR-126 in the 3’-UTR OF CD97
This interaction may facilitate cell activation and migration through the blood-brain barrier. In addition, cd97-cd55 interactions in the parenchyma of the brain may contribute to the inflammation.