| + |
NHEJ1 | up-regulates activity 
binding
|
Lig4-Xrcc4 complex |
0.826 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276883 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 25661488 |
Here we report that Akt phosphorylates XLF (XRCC4 like factor, also called NHEJ1) at T181, to dissociate XLF from the XRCC4 (X-ray repair cross-complementing protein 4)/DNA ligase IV (LIG4) complex and subsequently triggers XLF cytoplasmic translocation, leading to XLF ubiquitination by SCFβ-TRCP in a CKI-dependent manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Lig4-Xrcc4 complex | up-regulates
|
DNA_repair |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264534 |
|
|
in vitro |
|
| pmid |
sentence |
| 19837014 |
The DNA ligase IV-Xrcc4 complex is responsible for the ligation of broken DNA ends in the non-homologous end-joining (NHEJ) pathway of DNA double strand break repair in mammals. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
LIG4 | form complex 
binding
|
Lig4-Xrcc4 complex |
0.95 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264533 |
|
|
in vitro |
|
| pmid |
sentence |
| 19837014 |
The DNA ligase IV-Xrcc4 complex is responsible for the ligation of broken DNA ends in the non-homologous end-joining (NHEJ) pathway of DNA double strand break repair in mammals. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
XRCC4 | form complex
binding
|
Lig4-Xrcc4 complex |
0.95 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264532 |
|
|
in vitro |
|
| pmid |
sentence |
| 19837014 |
The DNA ligase IV-Xrcc4 complex is responsible for the ligation of broken DNA ends in the non-homologous end-joining (NHEJ) pathway of DNA double strand break repair in mammals. |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
Lig4-Xrcc4 complex
CPX-618