4.0
Summary
| Name |  KNTC1
|
| Full Name | Kinetochore-associated protein 1 |
| Synonyms | Rough deal homolog, HsROD, Rod, hRod | KIAA0166 |
| Primary ID | P50748 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (PubMed:11146660, PubMed:11590237, PubMed:15824131). Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | KNTC1 | form complex 
binding
|
RZZ complex | 0.763 |
| Publications: | 1 | Organism: | Homo Sapiens | |