Summary

Name RNF144A
Full Name E3 ubiquitin-protein ligase RNF144A
Synonyms RING finger protein 144A, UbcM4-interacting protein 4, Ubiquitin-conjugating enzyme 7-interacting protein 4 | KIAA0161, RNF144, UBCE7IP4
Primary ID P50876
Links - -
Type protein
Relations 2
Function E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC.

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Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination PRKDC 0.548
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination RNF144A 0.2
Publications: 1 Organism: Homo Sapiens