Relation Results

Summary

Name RNF144A
Full Name E3 ubiquitin-protein ligase RNF144A
Synonyms RING finger protein 144A, UbcM4-interacting protein 4, Ubiquitin-conjugating enzyme 7-interacting protein 4 | KIAA0161, RNF144, UBCE7IP4
Primary ID P50876
Links - -
Type protein
Relations 3
Function E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then direct ...
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Type: Score: Layout: SPV 
0.20.20.562RNF144APARP1Ub:E2PRKDC

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Relations
Regulator
Mechanism
target
score ℹ
+ RNF144Adown-regulates quantity by destabilization img/direct_inhibition.png ubiquitination PARP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-278776 Homo sapiens
pmid sentence
As RNF144A is a newly characterized E3 ubiquitin ligase , ], we next investigated whether RNF144A could promote PARP1 ubiquitination.|RNF144A promotes the proteasomal degradation of PARP1.
Publications: 1 Organism: Homo Sapiens
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination RNF144A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271154 Homo sapiens
pmid sentence
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t
Publications: 1 Organism: Homo Sapiens
+ RNF144Adown-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination PRKDC 0.562
Identifier Residue Sequence Organism Cell Line
SIGNOR-272213 Homo sapiens HEK-293 Cell
pmid sentence
We show that RNF144A induces ubiquitination of DNA-PKcs in vitro and in vivo and promotes its degradation.
Publications: 1 Organism: Homo Sapiens
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