Name CCR4
Full Name C-C chemokine receptor type 4
Synonyms C-C CKR-4, CC-CKR-4, CCR-4, CCR4, K5-5 | CMKBR4
Primary ID P51679
Links - -
Type protein
Relations 1
Function High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.



Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding CCR4 0.08
Publications: 1 Organism: Homo Sapiens