Summary

Name NEK3
Full Name Serine/threonine-protein kinase Nek3
Synonyms HSPK 36, Never in mitosis A-related kinase 3, NimA-related protein kinase 3 |
Primary ID P51956
Links - -
Type protein
Relations 2
Function Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation SNAP29 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NEK3 0.2
Publications: 1 Organism: In Vitro