| + |
PRKCD | up-regulates activity 
phosphorylation
|
BLVRA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275525 |
Ser21 |
VGVGRAGsVRMRDLR |
|
|
| pmid |
sentence |
| 22584576 |
LC-MS/MS analysis of PKCdelta-activated intact hBVR identified phosphorylated serine positions 21, 33, 230, and 237, corresponding to the hBVR Src homology-2 domain motif (Ser(230) and Ser(237)), flanking the ATP-binding motif (Ser(21)) and in PHPS sequence (Ser(33)) as targets of PKCdelta. |PKCdelta potentiated hBVR reductase activity and accelerated the rate of bilirubin formation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275526 |
Ser237 |
SFHFKSGsLENVPNV |
|
|
| pmid |
sentence |
| 22584576 |
LC-MS/MS analysis of PKCdelta-activated intact hBVR identified phosphorylated serine positions 21, 33, 230, and 237, corresponding to the hBVR Src homology-2 domain motif (Ser(230) and Ser(237)), flanking the ATP-binding motif (Ser(21)) and in PHPS sequence (Ser(33)) as targets of PKCdelta. |PKCdelta potentiated hBVR reductase activity and accelerated the rate of bilirubin formation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275527 |
Ser33 |
DLRNPHPsSAFLNLI |
|
|
| pmid |
sentence |
| 22584576 |
LC-MS/MS analysis of PKCdelta-activated intact hBVR identified phosphorylated serine positions 21, 33, 230, and 237, corresponding to the hBVR Src homology-2 domain motif (Ser(230) and Ser(237)), flanking the ATP-binding motif (Ser(21)) and in PHPS sequence (Ser(33)) as targets of PKCdelta. |PKCdelta potentiated hBVR reductase activity and accelerated the rate of bilirubin formation. |
|
| Publications: |
3 |
| + |
AKT1 | up-regulates activity
phosphorylation
|
BLVRA |
0.302 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275517 |
Ser230 |
LKRNRYLsFHFKSGS |
|
|
| pmid |
sentence |
| 15870194 |
Site-directed mutagenesis, mass spectrometry, and kinetic analyses identified S(230) in hBVR (225)RNRYLSF sequence as the Akt1 target. |
|
| Publications: |
1 |
| + |
BLVRA | up-regulates
phosphorylation
|
PRKCB |
0.311 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152181 |
Thr500 |
WDGVTTKtFCGTPDY |
Homo sapiens |
|
| pmid |
sentence |
| 17227757 |
Human biliverdin reductase, a previously unknown activator of protein kinase c ?II the phosphorylation of thr500 was confirmed by immunoblotting of hbvr.pkc betaii immunocomplex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
INSR | up-regulates activity
phosphorylation
|
BLVRA |
0.494 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275514 |
Tyr198 |
EERKEDQyMKMTVCL |
|
|
| pmid |
sentence |
| 15870194 |
Human BVR (hBVR) also reduces the hemeoxygenase activity product biliverdin to bilirubin and is directly activated by insulin receptor kinase (IRK).|in addition to Y198 in the YMKM motif, 2 other tyrosines, Y228 in the YLSF motif and Y291 in the C-terminus of the protein, are directly phosphorylated by IRK |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275515 |
Tyr228 |
PGLKRNRyLSFHFKS |
|
|
| pmid |
sentence |
| 15870194 |
Human BVR (hBVR) also reduces the hemeoxygenase activity product biliverdin to bilirubin and is directly activated by insulin receptor kinase (IRK).|in addition to Y198 in the YMKM motif, 2 other tyrosines, Y228 in the YLSF motif and Y291 in the C-terminus of the protein, are directly phosphorylated by IRK |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275516 |
Tyr291 |
LAEEIQKyCCSRK |
|
|
| pmid |
sentence |
| 15870194 |
Human BVR (hBVR) also reduces the hemeoxygenase activity product biliverdin to bilirubin and is directly activated by insulin receptor kinase (IRK).|in addition to Y198 in the YMKM motif, 2 other tyrosines, Y228 in the YLSF motif and Y291 in the C-terminus of the protein, are directly phosphorylated by IRK |
|
| Publications: |
3 |
| + |
BLVRA | up-regulates quantity
chemical modification
|
biliverdin(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275521 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7929092 |
This report describes for the first time the identification of four forms of biliverdin reductase including two biliverdin-IX beta reductases and two biliverdin-IX alpha reductases, designated isozymes I and II and isozymes III and IV, respectively, in human liver cytosolic fractions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Liver |
| + |
BLVRA | down-regulates quantity 
chemical modification
|
bilirubin(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275520 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7929092 |
This report describes for the first time the identification of four forms of biliverdin reductase including two biliverdin-IX beta reductases and two biliverdin-IX alpha reductases, designated isozymes I and II and isozymes III and IV, respectively, in human liver cytosolic fractions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Liver |
3.0
BLVRA
- 
- 