Summary

Name SLC25A1
Full Name Tricarboxylate transport protein, mitochondrial
Synonyms Citrate transport protein, CTP, Solute carrier family 25 member 1, Tricarboxylate carrier protein | SLC20A3
Primary ID P53007
Links - -
Type protein
Relations 2
Pathways Fatty Acid Synthesis, Glycolysis and Gluconeogenesis
Function Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate (PubMed:29031613, PubMed:29238895). Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate (PubMed:29031613). Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation (Probable).

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Relations

Regulator Mechanism target score
+ up-regulates quantity img/direct-activation.png relocalization D-threo-isocitrate(3-) 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png relocalization citrate(3-) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Fatty Acid Synthesis, Glycolysis and Gluconeogenesis