Summary

Name ARFIP2
Full Name Arfaptin-2
Synonyms ADP-ribosylation factor-interacting protein 2, Partner of RAC1, Protein POR1 | POR1
Primary ID P53365
Links - -
Type protein
Relations 2
Function Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2 (PubMed:26507660). Participates also in autophagy by regulating the starvation-depdendent trafficking of ATG9A vesicles which deliver the PI4-kinase to the autophagosome initiation site (PubMed:31204568). In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG (PubMed:26296658).

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation ARFIP2 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation ARFIP2 0.476
Publications: 1 Organism: Homo Sapiens