Summary

Name EPHB4
Full Name Ephrin type-B receptor 4
Synonyms Hepatoma transmembrane kinase, Tyrosine-protein kinase TYRO11 | HTK, MYK1, TYRO11
Primary ID P54760
Links - -
Type protein
Relations 3
Inhibitors 4-methyl-3-[[1-methyl-6-(3-pyridinyl)-4-pyrazolo[3,4-d]pyrimidinyl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide
Function Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells.

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Relations

Regulator Mechanism target score ℹ
+ EPHB4up-regulates activity img/direct-activation.png phosphorylation NOS3 0.311
Publications: 1 Organism: Homo Sapiens
+ 4-methyl-3-[[1-methyl-6-(3-pyridinyl)-4-pyrazolo[3,4-d]pyrimidinyl]amino]-N-[3-(trifluoromethyl)phenyl]benzamidedown-regulates img/direct_inhibition.png chemical inhibition EPHB4 0.8
Publications: 1 Organism: Homo Sapiens
+ EFNB1up-regulates img/direct-activation.png binding EPHB4 0.752
Publications: 1 Organism: Homo Sapiens