| + |
EFNB1 | up-regulates 
binding
|
EPHB1 |
0.822 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-111851 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11713248 |
We show here that despite its lack of kinase activity, ephb6 undergoes inducible tyrosine phosphorylation upon stimulation with the eph-b receptor subfamily ligand ephrin-b1. Overexpression of a catalytically active member of the eph-b subfamily, ephb1, resulted in increased ephb6 phosphorylation. Ephb1-induced ephb6 phosphorylation was ligand-dependent and required the functional catalytic activity of ephb1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EFNB1 | up-regulates
binding
|
EPHB4 |
0.745 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-52580 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9330863 |
Receptors of the epha group preferentially interact with glycosylphosphatidylinositol (gpi)-linked ligands (of the ephrin-a subclass, which comprises five ligands), while receptors of the ephb group preferentially interact with transmembrane ligands (of the ephrin-b subclass, which comprises three ligands) (table 1). In either case, binding of a ligand results in eph receptor autophosphorylation on tyrosine residues and activation of the kinase activity of the eph receptor |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN13 | up-regulates activity
dephosphorylation
|
EFNB1 |
0.697 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277002 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23811940 |
Loss of PTPN13 function increases EFNB1 phosphorylation, enhances EFNB1 's interaction with ERBB1 and correlates with potentiated ERK1/2 activation.|Moreover, acquisition of PTPN13 loss-of-function mutations or its decreased expression (due to HPV infection or epigenetic silencing) may further enhance ERBB1 and EFNB1 mediated signals. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EFNB1 | up-regulates
binding
|
EPHB3 |
0.754 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-52517 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9330863 |
The activation of eph receptors by their ligands, which are membrane-anchored molecules, involves a cell-cell recognition event that often causes cell repulsion. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
EFNB1
- 
- 