3.0
Summary
| Name |  HMGCS2View Modifications |
| Full Name | Hydroxymethylglutaryl-CoA synthase, mitochondrial |
| Synonyms | HMG-CoA synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthase | |
| Primary ID | P54868 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SIRT5 | up-regulates activity 
post translational modification
|
HMGCS2 | 0.349 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | HMGCS2 | down-regulates quantity 
chemical modification
|
acetoacetyl-CoA | 0.8 |
| Publications: | 1 | |||
| + | HMGCS2 | up-regulates quantity
chemical modification
|
(3S)-3-hydroxy-3-methylglutaryl-CoA(5-) | 0.8 |
| Publications: | 1 | |||
| + | HMGCS2 | down-regulates quantity
chemical modification
|
acetyl-CoA | 0.8 |
| Publications: | 1 | |||