Relation Results

Summary

Name TMBIM6
Full Name Bax inhibitor 1
Synonyms BI-1, Testis-enhanced gene transcript protein, Transmembrane BAX inhibitor motif-containing protein 6 | BI1, TEGT
Primary ID P55061
Links - -
Type protein
Relations 1
Function Suppressor of apoptosis (PubMed:21075086). Modulates unfolded protein response signaling (PubMed:21075086). Modulates ER calcium homeostasis by acting ...
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Type: Score: Layout: SPV 
0.394BFARTMBIM6

Relations

Regulator
Mechanism
target
score
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination TMBIM6 0.394
Identifier Residue Sequence Organism Cell Line
SIGNOR-272778 Homo sapiens HEK-293 Cell
pmid sentence
BAR overexpression promotes BI-1 ubiquitination and proteasomal degradation.We show here that bifunctional apoptosis regulator (BAR) functions as an ER-associated RING-type E3 ligase, interacts with BI-1, and promotes proteasomal degradation of BI-1. 
Publications: 1 Organism: Homo Sapiens
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