Summary

Name ARPP19
Full Name cAMP-regulated phosphoprotein 19
Synonyms ARPP-19
Primary ID P56211
Links - -
Type protein
Relations 2
Function Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation ARPP19 0.721
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png binding PPP2R2D 0.683
Publications: 1 Organism: In Vitro