Summary

Name ARPC4
Full Name Actin-related protein 2/3 complex subunit 4
Synonyms Arp2/3 complex 20 kDa subunit, p20-ARC | ARC20
Primary ID P59998
Links - -
Type protein
Relations 1
Function Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).

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Relations

Regulator Mechanism target score ℹ
+ ARPC4form complex img/form-complex.png binding ARP2/3 0.964
Publications: 1 Organism: Homo Sapiens