Relation Results

Summary

Name RAC3
Full Name Ras-related C3 botulinum toxin substrate 3
Synonyms p21-Rac3
Primary ID P60763
Links - -
Type protein
Relations 3
Function Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of e ...
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Type: Score: Layout: SPV 
0.5540.3490.2SRGAP3RAC3CIB1DEAF1

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Relations
Regulator
Mechanism
target
score ℹ
+ SRGAP3down-regulates img/indirect_inhibition.png RAC3 0.554
Identifier Residue Sequence Organism Cell Line
SIGNOR-95964 Homo sapiens
pmid sentence
Wrp binds directly to wave-1 through its src homology domain 3 and specifically inhibits rac function in vivo.
Publications: 1 Organism: Homo Sapiens
+ RAC3up-regulates activity img/direct-activation.png binding CIB1 0.349
Identifier Residue Sequence Organism Cell Line
SIGNOR-269060 Cricetulus griseus CHO Cell
pmid sentence
We here report that CIB, a protein that binds to the alpha(IIb)beta(3) fibrinogen receptor, interacts exclusively with activated (V12) Rac3 but not Rac1 or Rac2. Binding of V12Rac3 to CIB was mediated by the C-terminal end of Rac3 and by Rac3 membrane localization
Publications: 1 Organism: Cricetulus Griseus
+ DEAF1up-regulates quantity by expression img/direct-activation.png transcriptional regulation RAC3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269059 Homo sapiens MCF-10A Cell
pmid sentence
Affymetrix gene profiling studies revealed Rac3 as a potential target gene and quantitative RT-PCR analysis confirmed that Rac3 was upregulated by Deaf-1 in immortalized mouse mammary epithelial cells.
Publications: 1 Organism: Homo Sapiens
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