Summary

Name RAC3
Full Name Ras-related C3 botulinum toxin substrate 3
Synonyms p21-Rac3
Primary ID P60763
Links - -
Type protein
Relations 3
Function Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner.

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation RAC3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CIB1 0.354
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates img/indirect_inhibition.png RAC3 0.538
Publications: 1 Organism: Homo Sapiens