Summary

Name DAD1
Full Name Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
Synonyms Oligosaccharyl transferase subunit DAD1, Defender against cell death 1, DAD-1 |
Primary ID P61803
Links - -
Type protein
Relations 2
Function Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:22467853, PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes. Loss of the DAD1 protein triggers apoptosis (PubMed:22467853).

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Relations

Regulator Mechanism target score ℹ
+ DAD1form complex img/form-complex.png binding OST-A complex 0.733
Publications: 1 Organism: Homo Sapiens
+ DAD1form complex img/form-complex.png binding OST-B complex 0.709
Publications: 1 Organism: Homo Sapiens