Summary

Name UBE2H
Full Name Ubiquitin-conjugating enzyme E2 H
Synonyms (E3-independent) E2 ubiquitin-conjugating enzyme H, 2.3.2.24, E2 ubiquitin-conjugating enzyme H, UbcH2, Ubiquitin carrier protein H, Ubiquitin-conjugating enzyme E2-20K, Ubiquitin-protein ligase H |
Primary ID P62256
Links - -
Type protein
Relations 3
Function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:8132613, PubMed:17588522, PubMed:20061386). E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination (PubMed:20061386). Capable, in vitro, to ubiquitinate histone H2A (PubMed:8132613).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png ubiquitination UBE2H 0.489
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation UBE2H 0.333
Publications: 1
+ up-regulates activity img/direct-activation.png ubiquitination UBE2H 0.747
Publications: 1 Organism: Homo Sapiens