Synonyms |
Histone H2B.1 A, Histone H2B.a, H2B/a, Histone H2B.g, H2B/g, Histone H2B.h, H2B/h, Histone H2B.k, H2B/k, Histone H2B.l, H2B/l | H2BFL, HIST1H2BE, HIST1H2BF, HIST1H2BG, HIST1H2BI, HIST1H2BE, HIST1H2BF, HIST1H2BG, HIST1H2BI, HIST1H2BE, HIST1H2BF, HIST1H2BG, HIST1H2BI, HIST1H2BE, HIST1H2BF, HIST1H2BG, HIST1H2BI, H2BC6, H2BC7, H2BC8, H2BC10, H2BC6, H2BC7, H2BC8, H2BC10, H2BC6, H2BC7, H2BC8, H2BC10 |
Function |
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION |