Summary

Name TRA2B
Full Name Transformer-2 protein homolog beta
Synonyms TRA-2 beta, TRA2-beta, hTRA2-beta, Splicing factor, arginine/serine-rich 10, Transformer-2 protein homolog B | SFRS10
Primary ID P62995
Links - -
Type protein
Relations 2
Function Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation TRA2B 0.679
Publications: 2 Organism: Homo Sapiens