4.0
Summary
| Name |  SEC11A
|
| Full Name | Signal peptidase complex catalytic subunit SEC11A |
| Synonyms | Endopeptidase SP18, Microsomal signal peptidase 18 kDa subunit, SPase 18 kDa subunit, SEC11 homolog A, SEC11-like protein 1, SPC18 | SEC11L1, SPC18, SPCS4A |
| Primary ID | P67812 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (PubMed:34388369). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SEC11A | form complex 
binding
|
Signal peptidase complex, SEC11A variant | 0.701 |
| Publications: | 1 | Organism: | Homo Sapiens | |