Summary

Name PRAME
Full Name Melanoma antigen preferentially expressed in tumors
Synonyms Opa-interacting protein 4, OIP-4, Preferentially expressed antigen of melanoma | MAPE, OIP4
Primary ID P78395
Links - -
Type protein
Relations 1
Function Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.

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Relations

Regulator Mechanism target score
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PRAME 0.326
Publications: 1 Organism: Homo Sapiens