| + |
ROCK1 | up-regulates 
phosphorylation
|
SOX9 |
0.305 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-162643 |
Ser181 |
YQPRRRKsVKNGQAE |
Homo sapiens |
|
| pmid |
sentence |
| 20039424 |
Rho kinase-dependent activation of sox9 in chondrocytes. In vitro, rock directly phosphorylated sox9 at ser(181), and the overexpression of rock or the activation of the rhoa pathway in sw1353 chondrosarcoma cells increased sox9(ser181) phosphorylation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADCK5 | up-regulates activity
phosphorylation
|
SOX9 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264567 |
Ser181 |
YQPRRRKsVKNGQAE |
|
|
| pmid |
sentence |
| 32277958 |
Here we investigated the mechanism of ADCK5 involved in regulating invasion and migration of lung cancer cells, and showed that ADCK5 might regulate the expression of tumor oncogene human pituitary tumor transforming gene-1 (PTTG1) by phosphorylating transcription factor SOX9|Mutagenesis of potential serine phosphorylation sites on SOX9 indicated that serine 181 might be required to maintain transcription activation of SOX9 as well as increase PTTG1 levels. |
|
| Publications: |
1 |
| + |
PRKACA | up-regulates
phosphorylation
|
SOX9 |
0.464 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-137085 |
Ser181 |
YQPRRRKsVKNGQAE |
Homo sapiens |
|
| pmid |
sentence |
| 15889150 |
We find that activation of camp-dependent protein kinase a (pka) induces phosphorylation of sox9 on its two s64 and s181 pka sites, and its nuclear localization by enhancing sox9 binding to the nucleocytoplasmic transport protein importin beta. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-137089 |
Ser64 |
EPDLKKEsEEDKFPV |
Homo sapiens |
|
| pmid |
sentence |
| 15889150 |
We find that activation of camp-dependent protein kinase a (pka) induces phosphorylation of sox9 on its two s64 and s181 pka sites, and its nuclear localization by enhancing sox9 binding to the nucleocytoplasmic transport protein importin beta. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CDKL5 | down-regulates activity 
phosphorylation
|
SOX9 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279457 |
Ser199 |
ATEQTHIsPNAIFKA |
Homo sapiens |
|
| pmid |
sentence |
| 32317630 |
Based on these studies, we hypothesized that Cdkl5 dependent phosphorylation at Ser 199 suppresses Sox9 function during AKI.|We also found that Cdkl5 phosphorylates Sox9 at Ser 199 residue during kidney injury in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GSK3B | down-regulates activity
phosphorylation
|
SOX9 |
0.445 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279725 |
Thr236 |
GQSQGPPtPPTTPKT |
Homo sapiens |
|
| pmid |
sentence |
| 27566146 |
(E) The SOX9 K2 domain is phosphorylated by GSK3\u03b2 at T236.|Based on our findings that inhibition of GSK3\u03b2 prevents DNA damage-induced SOX9 degradation, and that FBW7 targets SOX9 for degradation after DNA damage, we reasoned that phosphorylation of SOX9 by GSK3\u03b2 is required for FBW7-mediated SOX9 degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX9 | down-regulates quantity by repression 
transcriptional regulation
|
CDX2 |
0.381 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253322 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15240568 |
SOX9 represses the expression of the CDX2 transcription factor, known to be mostly active in villus cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DLK1 | up-regulates 
transcriptional regulation
|
SOX9 |
0.391 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209968 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19254573 |
Pref-1 inhibits adipocyte differentiation through upregulating sox9 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX9 | up-regulates quantity by expression
transcriptional regulation
|
COL2A1 |
0.502 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251756 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10980415 |
Since Sox9 also contains a potent transcription activation domain, it is a typical transcription factor. Sox9 which binds and activates this enhancer element, is required for chondrocyte differentiation and for expression of a series of chondrocyte-specific marker genes including Col2a1, Col9a2, Col11a2 and Aggrecan. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX9 | up-regulates quantity by expression
transcriptional regulation
|
COL11A2 |
0.387 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251758 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10980415 |
Since Sox9 also contains a potent transcription activation domain, it is a typical transcription factor. Sox9 which binds and activates this enhancer element, is required for chondrocyte differentiation and for expression of a series of chondrocyte-specific marker genes including Col2a1, Col9a2, Col11a2 and Aggrecan. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX9 | down-regulates quantity by repression
transcriptional regulation
|
PRAME |
0.317 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255191 |
|
|
Homo sapiens |
Melanoma Cell Line |
| pmid |
sentence |
| 19273910 |
Overexpression of SOX9 in both human and mouse melanoma cell lines induced cell cycle arrest by increasing p21 transcription and restored sensitivity to RA by downregulating expression of PRAME, a melanoma antigen. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX9 | up-regulates quantity by expression
transcriptional regulation
|
DCC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255188 |
|
|
Homo sapiens |
Chondrocyte Cell Line |
| pmid |
sentence |
| 19745029 |
Promoter analysis and transfection studies showed that the up-regulation of DCC in OA chondrocytes may be mediated by the transcription factors Sox9 and AP-2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX9 | up-regulates activity
binding
|
OTX2 |
0.349 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255184 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20530484 |
BEST1 promoter activity was increased by SOX9 overexpression and decreased by siRNA-mediated SOX9 knockdown. SOX9 physically interacted with MITF and OTX2 and orchestrated synergistic activation of the BEST1 promoter with the paired SOX site playing essential roles. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SOX9 | up-regulates quantity by expression
transcriptional regulation
|
COL9A2 |
0.355 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251757 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10980415 |
Since Sox9 also contains a potent transcription activation domain, it is a typical transcription factor. Sox9 which binds and activates this enhancer element, is required for chondrocyte differentiation and for expression of a series of chondrocyte-specific marker genes including Col2a1, Col9a2, Col11a2 and Aggrecan. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX9 | up-regulates quantity by expression
transcriptional regulation
|
BEST1 |
0.332 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255187 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20530484 |
BEST1 promoter activity was increased by SOX9 overexpression and decreased by siRNA-mediated SOX9 knockdown. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SOX9 | up-regulates quantity by expression
transcriptional regulation
|
CDKN1A |
0.373 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255190 |
|
|
Homo sapiens |
Melanoma Cell Line |
| pmid |
sentence |
| 19273910 |
Overexpression of SOX9 in both human and mouse melanoma cell lines induced cell cycle arrest by increasing p21 transcription and restored sensitivity to RA by downregulating expression of PRAME, a melanoma antigen. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | up-regulates
transcriptional regulation
|
SOX9 |
0.381 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209965 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20457810 |
Soluble pref-1 inhibits adipocyte differentiation through the activation of extracellular signal-regulated kinase/mitogen-activated protein kinase (erk/mapk) and the subsequent upregulation of sox9 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX9 | down-regulates quantity by repression
transcriptional regulation
|
CEBPD |
0.272 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184283 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19254573 |
Sox9 directly binds to the promoter regions of c/ebpbeta and c/ebpdelta to suppress their promoter activity, preventing adipocyte differentiation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERK1/2 | up-regulates
transcriptional regulation
|
SOX9 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244750 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20457810 |
Soluble pref-1 inhibits adipocyte differentiation through the activation of extracellular signal-regulated kinase/mitogen-activated protein kinase (erk/mapk) and the subsequent upregulation of sox9 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DLK1 | up-regulates quantity by expression
transcriptional regulation
|
SOX9 |
0.391 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184277 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19254573 |
Pref-1 inhibits adipocyte differentiation through upregulating sox9 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX9 | down-regulates quantity by repression
transcriptional regulation
|
CEBPB |
0.325 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184280 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19254573 |
Sox9 directly binds to the promoter regions of c/ebpbeta and c/ebpdelta to suppress their promoter activity, preventing adipocyte differentiation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | up-regulates quantity by expression
transcriptional regulation
|
SOX9 |
0.381 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165353 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20457810 |
Soluble pref-1 inhibits adipocyte differentiation through the activation of extracellular signal-regulated kinase/mitogen-activated protein kinase (erk/mapk) and the subsequent upregulation of sox9 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TCF4 | up-regulates quantity by expression
transcriptional regulation
|
SOX9 |
0.392 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253323 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15240568 |
The β-catenin–TCF4 complex activity is required for SOX9 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX9 | up-regulates activity
binding
|
MITF |
0.383 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255183 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20530484 |
BEST1 promoter activity was increased by SOX9 overexpression and decreased by siRNA-mediated SOX9 knockdown. SOX9 physically interacted with MITF and OTX2 and orchestrated synergistic activation of the BEST1 promoter with the paired SOX site playing essential roles. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PRKG2 | down-regulates activity
phosphorylation
|
SOX9 |
0.501 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278985 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19543319 |
Cyclic GMP-dependent protein kinase II inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lines|Prkg2 transfected glioma cell lines express a functional cGKII that can phosphorylate VASP and Sox9. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX9 | down-regulates
transcriptional regulation
|
CEBPB |
0.325 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210037 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19254573 |
Sox9 directly binds to the promoter regions of c/ebpbeta and c/ebpdelta to suppress their promoter activity, preventing adipocyte differentiation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
UBE3A | down-regulates quantity by destabilization
ubiquitination
|
SOX9 |
0.261 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272134 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 24155239 |
We show that E6-AP ubiquitinates SOX9 in vitro and in vivo and that SOX9 levels are enhanced after addition of the proteasome inhibitor bortezomib. Similar, siRNA knockdown of E6-AP and the E2 ligase Ubc9 increased cellular SOX9 amounts, supporting the notion that SOX9 may be ubiquitinated in hypertrophic chondrocytes by E6-AP and degraded by proteasomes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SOX9
- 
- 