3.0
Summary
| Name |  BLOC1S1
|
| Full Name | Biogenesis of lysosome-related organelles complex 1 subunit 1 |
| Synonyms | BLOC-1 subunit 1, GCN5-like protein 1, Protein RT14 | BLOS1, GCN5L1, RT14 |
| Primary ID | P78537 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (PubMed:17182842). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). |
binding