| + |
BLOC1S5 | form complex 
binding
|
BLOC-1 |
0.68 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265938 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22203680 |
We show that BLOC-1 is an elongated complex that contains one copy each of the eight subunits pallidin, Cappuccino, dysbindin, Snapin, Muted, BLOS1, BLOS2, and BLOS3. The complex appears as a linear chain of eight globular domains, ∼300 A long and ∼30 A in diameter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BLOC1S1 | form complex
binding
|
BLOC-1 |
0.72 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265936 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22203680 |
We show that BLOC-1 is an elongated complex that contains one copy each of the eight subunits pallidin, Cappuccino, dysbindin, Snapin, Muted, BLOS1, BLOS2, and BLOS3. The complex appears as a linear chain of eight globular domains, ∼300 A long and ∼30 A in diameter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BLOC-1 | up-regulates 
|
Platelet_dense_granule_formation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265940 |
|
|
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 12019270 |
BLOC-1, a novel complex containing the pallidin and muted proteins involved in the biogenesis of melanosomes and platelet-dense granules|Interestingly, immunofluorescence and in vitro binding experiments demonstrated that pallidin/BLOC-1 is able to associate with actin filaments. We propose that BLOC-1 mediates the biogenesis of lysosome-related organelles by a mechanism that may involve self-assembly and interaction with the actin cytoskeleton. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BLOC1S6 | form complex
binding
|
BLOC-1 |
0.724 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265931 |
|
|
Homo sapiens |
MNT-1 Cell |
| pmid |
sentence |
| 22203680 |
We show that BLOC-1 is an elongated complex that contains one copy each of the eight subunits pallidin, Cappuccino, dysbindin, Snapin, Muted, BLOS1, BLOS2, and BLOS3. The complex appears as a linear chain of eight globular domains, ∼300 A long and ∼30 A in diameter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SNAPIN | form complex
binding
|
BLOC-1 |
0.712 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265935 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22203680 |
We show that BLOC-1 is an elongated complex that contains one copy each of the eight subunits pallidin, Cappuccino, dysbindin, Snapin, Muted, BLOS1, BLOS2, and BLOS3. The complex appears as a linear chain of eight globular domains, ∼300 A long and ∼30 A in diameter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BLOC-1 | up-regulates
|
Melanosome_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265939 |
|
|
Homo sapiens |
Melanocyte |
| pmid |
sentence |
| 22203680 |
Lysosome-related organelles (LROs) 6 are present in a range of cells in multicellular eukaryotes and include lytic granules, lung lamellar bodies, platelet-dense granules, and melanosomes (1.). The melanosome of the pigment cells in the skin and eye is the best studied of the LROs (1., 2.). The biogenesis of the melanosome and other LROs requires the AP-3 adaptor complex, the class C Vps complex, and three BLOC (biogenesis of lysosome-related organelles complex) complexes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BLOC1S2 | form complex
binding
|
BLOC-1 |
0.716 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265937 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22203680 |
We show that BLOC-1 is an elongated complex that contains one copy each of the eight subunits pallidin, Cappuccino, dysbindin, Snapin, Muted, BLOS1, BLOS2, and BLOS3. The complex appears as a linear chain of eight globular domains, ∼300 A long and ∼30 A in diameter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BLOC1S4 | form complex
binding
|
BLOC-1 |
0.613 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265932 |
|
|
Homo sapiens |
MNT-1 Cell |
| pmid |
sentence |
| 22203680 |
We show that BLOC-1 is an elongated complex that contains one copy each of the eight subunits pallidin, Cappuccino, dysbindin, Snapin, Muted, BLOS1, BLOS2, and BLOS3. The complex appears as a linear chain of eight globular domains, ∼300 A long and ∼30 A in diameter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BLOC1S3 | form complex
binding
|
BLOC-1 |
0.704 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265934 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22203680 |
We show that BLOC-1 is an elongated complex that contains one copy each of the eight subunits pallidin, Cappuccino, dysbindin, Snapin, Muted, BLOS1, BLOS2, and BLOS3. The complex appears as a linear chain of eight globular domains, ∼300 A long and ∼30 A in diameter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BLOC-1 | up-regulates quantity 
relocalization
|
serotonin |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265999 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23805129 |
The multidrug transporter MRP4, a multidrug resistance protein, is found on platelet dense granules and is proposed to transport adenine nucleotides into these granules (Jedlitschky et al., 2004). Uptake of serotonin from platelet cytosol into dense granules is mediated by vesicular monoamine transporter 2 (VMAT2). |VMAT2 also appears to mediate histamine transport into dense granules |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DTNBP1 | form complex
binding
|
BLOC-1 |
0.801 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265933 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22203680 |
We show that BLOC-1 is an elongated complex that contains one copy each of the eight subunits pallidin, Cappuccino, dysbindin, Snapin, Muted, BLOS1, BLOS2, and BLOS3. The complex appears as a linear chain of eight globular domains, ∼300 A long and ∼30 A in diameter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABCC4 | up-regulates activity
binding
|
BLOC-1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265996 |
|
|
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 23805129 |
The multidrug transporter MRP4, a multidrug resistance protein, is found on platelet dense granules and is proposed to transport adenine nucleotides into these granules (Jedlitschky et al., 2004). Uptake of serotonin from platelet cytosol into dense granules is mediated by vesicular monoamine transporter 2 (VMAT2). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC18A2 | up-regulates activity
binding
|
BLOC-1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265997 |
|
|
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 23805129 |
The multidrug transporter MRP4, a multidrug resistance protein, is found on platelet dense granules and is proposed to transport adenine nucleotides into these granules (Jedlitschky et al., 2004). Uptake of serotonin from platelet cytosol into dense granules is mediated by vesicular monoamine transporter 2 (VMAT2). |VMAT2 also appears to mediate histamine transport into dense granules |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BLOC-1 | up-regulates quantity
relocalization
|
histamine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265998 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23805129 |
The multidrug transporter MRP4, a multidrug resistance protein, is found on platelet dense granules and is proposed to transport adenine nucleotides into these granules (Jedlitschky et al., 2004). Uptake of serotonin from platelet cytosol into dense granules is mediated by vesicular monoamine transporter 2 (VMAT2). |VMAT2 also appears to mediate histamine transport into dense granules |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
BLOC-1
CPX-1910