Relation Results

Summary

Name BLOC-1
Primary ID SIGNOR-C381
Links CPX-1910
Type complex
Formed by BLOC1S6, BLOC1S4, BLOC1S1, BLOC1S2, BLOC1S5, SNAPIN, BLOC1S3, DTNBP1
Relations 14

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Type: Score: Layout: SPV 
0.7340.7220.70.6260.7140.80.20.20.7310.8080.70.6910.80.726BLOC1S6BLOC-1SNAPINMelanosome_assemblyBLOC1S4BLOC1S3serotoninABCC4SLC18A2BLOC1S1DTNBP1Platelet_dense_granule_formationBLOC1S5histamineBLOC1S2

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Relations
Regulator
Mechanism
target
score ℹ
+ BLOC1S6form complex img/form-complex.png binding BLOC-1 0.734
Identifier Residue Sequence Organism Cell Line
SIGNOR-265931 Homo sapiens MNT-1 Cell
pmid sentence
We show that BLOC-1 is an elongated complex that contains one copy each of the eight subunits pallidin, Cappuccino, dysbindin, Snapin, Muted, BLOS1, BLOS2, and BLOS3. The complex appears as a linear chain of eight globular domains, ∼300 A long and ∼30 A in diameter.
Publications: 1 Organism: Homo Sapiens
+ SNAPINform complex img/form-complex.png binding BLOC-1 0.722
Identifier Residue Sequence Organism Cell Line
SIGNOR-265935 Homo sapiens
pmid sentence
We show that BLOC-1 is an elongated complex that contains one copy each of the eight subunits pallidin, Cappuccino, dysbindin, Snapin, Muted, BLOS1, BLOS2, and BLOS3. The complex appears as a linear chain of eight globular domains, ∼300 A long and ∼30 A in diameter.
Publications: 1 Organism: Homo Sapiens
+ BLOC-1up-regulates img/indirect-activation.png Melanosome_assembly 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-265939 Homo sapiens Melanocyte
pmid sentence
Lysosome-related organelles (LROs) 6 are present in a range of cells in multicellular eukaryotes and include lytic granules, lung lamellar bodies, platelet-dense granules, and melanosomes (1.). The melanosome of the pigment cells in the skin and eye is the best studied of the LROs (1., 2.). The biogenesis of the melanosome and other LROs requires the AP-3 adaptor complex, the class C Vps complex, and three BLOC (biogenesis of lysosome-related organelles complex) complexes
Publications: 1 Organism: Homo Sapiens
+ BLOC1S4form complex img/form-complex.png binding BLOC-1 0.626
Identifier Residue Sequence Organism Cell Line
SIGNOR-265932 Homo sapiens MNT-1 Cell
pmid sentence
We show that BLOC-1 is an elongated complex that contains one copy each of the eight subunits pallidin, Cappuccino, dysbindin, Snapin, Muted, BLOS1, BLOS2, and BLOS3. The complex appears as a linear chain of eight globular domains, ∼300 A long and ∼30 A in diameter.
Publications: 1 Organism: Homo Sapiens
+ BLOC1S3form complex img/form-complex.png binding BLOC-1 0.714
Identifier Residue Sequence Organism Cell Line
SIGNOR-265934 Homo sapiens
pmid sentence
We show that BLOC-1 is an elongated complex that contains one copy each of the eight subunits pallidin, Cappuccino, dysbindin, Snapin, Muted, BLOS1, BLOS2, and BLOS3. The complex appears as a linear chain of eight globular domains, ∼300 A long and ∼30 A in diameter.
Publications: 1 Organism: Homo Sapiens
+ BLOC-1up-regulates quantity img/direct-activation.png relocalization serotonin 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-265999 Homo sapiens
pmid sentence
The multidrug transporter MRP4, a multidrug resistance protein, is found on platelet dense granules and is proposed to transport adenine nucleotides into these granules (Jedlitschky et al., 2004). Uptake of serotonin from platelet cytosol into dense granules is mediated by vesicular monoamine transporter 2 (VMAT2). |VMAT2 also appears to mediate histamine transport into dense granules
Publications: 1 Organism: Homo Sapiens
+ ABCC4up-regulates activity img/direct-activation.png binding BLOC-1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265996 Homo sapiens Blood Platelet
pmid sentence
The multidrug transporter MRP4, a multidrug resistance protein, is found on platelet dense granules and is proposed to transport adenine nucleotides into these granules (Jedlitschky et al., 2004). Uptake of serotonin from platelet cytosol into dense granules is mediated by vesicular monoamine transporter 2 (VMAT2). 
Publications: 1 Organism: Homo Sapiens
+ SLC18A2up-regulates activity img/direct-activation.png binding BLOC-1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265997 Homo sapiens Blood Platelet
pmid sentence
The multidrug transporter MRP4, a multidrug resistance protein, is found on platelet dense granules and is proposed to transport adenine nucleotides into these granules (Jedlitschky et al., 2004). Uptake of serotonin from platelet cytosol into dense granules is mediated by vesicular monoamine transporter 2 (VMAT2). |VMAT2 also appears to mediate histamine transport into dense granules
Publications: 1 Organism: Homo Sapiens
+ BLOC1S1form complex img/form-complex.png binding BLOC-1 0.731
Identifier Residue Sequence Organism Cell Line
SIGNOR-265936 Homo sapiens
pmid sentence
We show that BLOC-1 is an elongated complex that contains one copy each of the eight subunits pallidin, Cappuccino, dysbindin, Snapin, Muted, BLOS1, BLOS2, and BLOS3. The complex appears as a linear chain of eight globular domains, ∼300 A long and ∼30 A in diameter.
Publications: 1 Organism: Homo Sapiens
+ DTNBP1form complex img/form-complex.png binding BLOC-1 0.808
Identifier Residue Sequence Organism Cell Line
SIGNOR-265933 Homo sapiens
pmid sentence
We show that BLOC-1 is an elongated complex that contains one copy each of the eight subunits pallidin, Cappuccino, dysbindin, Snapin, Muted, BLOS1, BLOS2, and BLOS3. The complex appears as a linear chain of eight globular domains, ∼300 A long and ∼30 A in diameter.
Publications: 1 Organism: Homo Sapiens
+ BLOC-1up-regulates img/indirect-activation.png Platelet_dense_granule_formation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-265940 Homo sapiens Blood Platelet
pmid sentence
BLOC-1, a novel complex containing the pallidin and muted proteins involved in the biogenesis of melanosomes and platelet-dense granules|Interestingly, immunofluorescence and in vitro binding experiments demonstrated that pallidin/BLOC-1 is able to associate with actin filaments. We propose that BLOC-1 mediates the biogenesis of lysosome-related organelles by a mechanism that may involve self-assembly and interaction with the actin cytoskeleton.
Publications: 1 Organism: Homo Sapiens
+ BLOC1S5form complex img/form-complex.png binding BLOC-1 0.691
Identifier Residue Sequence Organism Cell Line
SIGNOR-265938 Homo sapiens
pmid sentence
We show that BLOC-1 is an elongated complex that contains one copy each of the eight subunits pallidin, Cappuccino, dysbindin, Snapin, Muted, BLOS1, BLOS2, and BLOS3. The complex appears as a linear chain of eight globular domains, ∼300 A long and ∼30 A in diameter.
Publications: 1 Organism: Homo Sapiens
+ BLOC-1up-regulates quantity img/direct-activation.png relocalization histamine 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-265998 Homo sapiens
pmid sentence
The multidrug transporter MRP4, a multidrug resistance protein, is found on platelet dense granules and is proposed to transport adenine nucleotides into these granules (Jedlitschky et al., 2004). Uptake of serotonin from platelet cytosol into dense granules is mediated by vesicular monoamine transporter 2 (VMAT2). |VMAT2 also appears to mediate histamine transport into dense granules
Publications: 1 Organism: Homo Sapiens
+ BLOC1S2form complex img/form-complex.png binding BLOC-1 0.726
Identifier Residue Sequence Organism Cell Line
SIGNOR-265937 Homo sapiens
pmid sentence
We show that BLOC-1 is an elongated complex that contains one copy each of the eight subunits pallidin, Cappuccino, dysbindin, Snapin, Muted, BLOS1, BLOS2, and BLOS3. The complex appears as a linear chain of eight globular domains, ∼300 A long and ∼30 A in diameter.
Publications: 1 Organism: Homo Sapiens
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