+ |
MAPK8 | up-regulates activity
phosphorylation
|
ARHGAP8 |
0.334 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-275550 |
Ser455 |
TKPTLPPsPLMAARR |
|
|
pmid |
sentence |
28092672 |
Furthermore, we identify that BPGAP1 (a BCH domain-containing, Cdc42GAP-like Rho GTPase-activating protein) promotes MEK partner 1 (MP1)-induced ERK activation on late endosome through scaffolding MP1/MEK1 complex. This regulatory function requires phosphorylation of BPGAP1 by JNK at its C terminal tail (Ser424) to unlock its autoinhibitory conformation. |
|
Publications: |
1 |
+ |
ARHGAP8 | up-regulates activity
binding
|
LAMTOR3 |
0.255 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-275551 |
|
|
|
|
pmid |
sentence |
28092672 |
Furthermore, we identify that BPGAP1 (a BCH domain-containing, Cdc42GAP-like Rho GTPase-activating protein) promotes MEK partner 1 (MP1)-induced ERK activation on late endosome through scaffolding MP1/MEK1 complex. This regulatory function requires phosphorylation of BPGAP1 by JNK at its C terminal tail (Ser424) to unlock its autoinhibitory conformation. |
|
Publications: |
1 |
+ |
ARHGAP8 | down-regulates activity
gtpase-activating protein
|
RHOA |
0.438 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260463 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
32203420 |
We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity among regulators, but also that the inactivating RhoGAPs are less selective than the activating RhoGEFs (p-value=0.02)(Supplementary Table 2). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |