| + |
RBM10 | down-regulates quantity by repression 
transcriptional regulation
|
CASP3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259152 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30403180 |
In this study, we report that RBM10 acts as a tumor suppressor in osteosarcoma via the inhibition of cell growth, cell migration and invasion and the induction of cell apoptosis by inhibiting Bcl-2, activating caspase-3, and producing TNF-α. We also found that RBM10 overexpression significantly inhibited the expression of Bcl-2 and induced the expression of caspase-3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RBM10 | down-regulates quantity by repression
transcriptional regulation
|
BCL2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259151 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30403180 |
In this study, we report that RBM10 acts as a tumor suppressor in osteosarcoma via the inhibition of cell growth, cell migration and invasion and the induction of cell apoptosis by inhibiting Bcl-2, activating caspase-3, and producing TNF-α. We also found that RBM10 overexpression significantly inhibited the expression of Bcl-2 and induced the expression of caspase-3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RBM10 | up-regulates 
|
Apoptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259150 |
|
|
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 30403180 |
Cell apoptosis is an important event in cancer progression. Overexpression of RBM10 dramatically induced U2OS cell apoptosis compared with negative control cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RBM10 | up-regulates quantity by expression
transcriptional regulation
|
TNF |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259153 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30403180 |
These data indicated that RBM10 overexpression induced osteosarcoma cell apoptosis via promoting the production of TNF-α that appear to act as an autocrine factor regulating osteosarcoma programmed cell death. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RBM10 | down-regulates
|
Proliferation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259149 |
|
|
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 30403180 |
Osteosarcoma is the most common malignant bone tumor with high incidence in adolescence and poor prognosis. RBM10, a member of RBPs, was reported to be a tumor suppressor in many kinds of cancers. The results showed that U2OS cell growth was significantly inhibited when RBM10 is overexpressed as compared with negative control cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
RBM10
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