Summary

Name IRF9
Full Name Interferon regulatory factor 9
Synonyms IRF-9, IFN-alpha-responsive transcription factor subunit, ISGF3 p48 subunit, Interferon-stimulated gene factor 3 gamma, ISGF-3 gamma, Transcriptional regulator ISGF3 subunit gamma | ISGF3G
Primary ID Q00978
Links - -
Type protein
Relations 4
Pathways Thyroid Hormone Metabolism
Function Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png acetylation IRF9 0.369
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ form complex img/form-complex.png binding ISGF3 complex 0.866
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding IFNAR2 0.716
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding STAT2 0.919
Publications: 1 Organism: Homo Sapiens