Summary

Name SET
Full Name Protein SET
Synonyms HLA-DR-associated protein II, Inhibitor of granzyme A-activated DNase, IGAAD, PHAPII, Phosphatase 2A inhibitor I2PP2A, I-2PP2A, Template-activating factor I, TAF-I |
Primary ID Q01105
Links - -
Type protein
Relations 5
Function Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher.

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Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png cleavage SET 0.66
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding PPP2CA 0.82
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png binding SET 0.36
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding NME1
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding PPP2CB 0.92
Publications: 1 Organism: Homo Sapiens
Tissue: Brain