| + |
CLN8 | down-regulates activity 
binding
|
SET |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265584 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 30453012 |
CLN8 interacts with ceramide binding proteins PP2A and I2PP2A. We showed that the phosphorylation levels of several substrates of PP2A, namely Akt, S6 kinase, and GSK3β, were decreased in CLN8 disease patient fibroblasts. This reduction can be reversed by inhibiting PP2A phosphatase activity with cantharidin, suggesting a higher PP2A activity in CLN8-deficient cells. The phosphorylation levels of PP2A substrates are decreased in the absence of CLN8. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CLN8 | up-regulates activity 
binding
|
PPP2CA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265583 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 30453012 |
CLN8 interacts with ceramide binding proteins PP2A and I2PP2A. We showed that the phosphorylation levels of several substrates of PP2A, namely Akt, S6 kinase, and GSK3β, were decreased in CLN8 disease patient fibroblasts. This reduction can be reversed by inhibiting PP2A phosphatase activity with cantharidin, suggesting a higher PP2A activity in CLN8-deficient cells. The phosphorylation levels of PP2A substrates are decreased in the absence of CLN8. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CLN8
- 
- 