3.0
Summary
| Name |  IFITM3View Modifications |
| Full Name | Interferon-induced transmembrane protein 3 |
| Synonyms | Dispanin subfamily A member 2b, DSPA2b, Interferon-inducible protein 1-8U | |
| Primary ID | Q01628 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit |
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phosphorylation