Summary

Name SPIB
Full Name Transcription factor Spi-B
Synonyms SPIB_HUMAN
Primary ID Q01892
Links - -
Type protein
Relations 9
Function Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation SPIB 0.14
Publications: 4 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SPIB 0.14
Publications: 4 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SPIB 0.14
Publications: 1 Organism: Homo Sapiens